The Science
Inflammation becomes systemic when three pathways converge: overactive inflammatory signaling, senescent cells secreting pro-inflammatory factors, and metabolic dysfunction that amplifies inflammation through insulin resistance and mitochondrial damage. These processes reinforce one another, accelerating tissue breakdown and aging.
How inflammation impacts healthspan
Interventions can help
Reduce inflammatory signaling
Overactive inflammatory cascades and cytokine production divert energy from repair to destruction throughout organ systems. Modulating these pathways restores cellular balance and tissue health.
Target senescence pathways
mTOR inhibition and autophagy enhancement clear senescent cells that secrete pro-inflammatory factors, so targeting cellular aging mechanisms helps reduce systemic inflammatory burden.
Optimize metabolic function
Insulin resistance and mitochondrial damage amplify inflammation through oxidative stress and metabolic dysfunction. Targeting metabolic pathways reduces inflammatory amplification and restores cellular efficiency.
Target senescence pathways
mTOR inhibition and autophagy enhancement clear senescent cells that secrete pro-inflammatory factors, so targeting cellular aging mechanisms helps reduce systemic inflammatory burden.
Reduce inflammatory signaling
Overactive inflammatory cascades and cytokine production divert energy from repair to destruction throughout organ systems. Modulating these pathways restores cellular balance and tissue health.
Optimize metabolic function
Insulin resistance and mitochondrial damage amplify inflammation through oxidative stress and metabolic dysfunction. Targeting metabolic pathways reduces inflammatory amplification and restores cellular efficiency.
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“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
Reviews
127 reviews
We study the studies
Healthspan longevity experts continuously review the latest clinical research, curating results to help deepen your understanding of aging science.