The role of mitochondria in healthspan

The Science of

(Energy)

Fatigue

cognitive performance

motivation

stress adaptation

The Science

 

Energy declines when our cells can’t produce enough power and stress takes a constant toll. Weak mitochondria and imbalanced stress hormones leave us feeling drained and slow to recover. Supporting mitochondrial health and calming stress pathways helps restore energy and rebuild vitality.

Cellular drivers of fatigue

image
(01)
Mitochondrial DeclineThe more we understand about how mitochondrial dysfunction reduces cellular energy production throughout the body, the more we can target metabolic deterioration before it becomes systemic and irreversible.
(02)
Stress DysregulationAdvances in neuroscience reveal how chronic stress and HPA-axis dysfunction disrupt recovery systems and deplete endogenous endorphins, driving fatigue cycles and reducing functional capacity across multiple systems.
(03)
Inflammatory ImpactResearch shows how chronic inflammation disrupts mitochondrial function and neurotransmitter production, creating cascading fatigue that compounds over time. Targeting inflammatory pathways restores cellular energy and cognitive resilience.

Target the Root Causes of Fatigue

Rebalance stress pathways

Prolonged stress shifts the body into survival mode, draining energy and slowing recovery. Oxytocin and LDN help regulate stress hormones and boost endorphins, restoring resilience and supporting calm, sustained energy.

Optimize mitochondrial function

As mitochondrial function declines with age, energy output falls, causing sluggishness, poor stamina, and brain fog. Compounds such as methylene blue and urolithin A improve mitochondrial quality, restore energy, and reduce fatigue.

Reduce neuroinflammation

Chronic inflammation in the brain disrupts neurotransmitter production and drains cellular energy throughout the body. Neuroimmune modulators like LDN help calm these signals, supporting clearer thinking, steady energy, and long-term cognitive vitality.

Optimize mitochondrial function

As mitochondrial function declines with age, energy output falls, causing sluggishness, poor stamina, and brain fog. Compounds such as methylene blue and urolithin A improve mitochondrial quality, restore energy, and reduce fatigue.

Rebalance stress pathways

Prolonged stress shifts the body into survival mode, draining energy and slowing recovery. Oxytocin and LDN help regulate stress hormones and boost endorphins, restoring resilience and supporting calm, sustained energy.

Reduce neuroinflammation

Chronic inflammation in the brain disrupts neurotransmitter production and drains cellular energy throughout the body. Neuroimmune modulators like LDN help calm these signals, supporting clearer thinking, steady energy, and long-term cognitive vitality.

becoming a patient

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How It Works
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Personal care for optimal health

Your dedicated care team is always by your side, helping to analyze your labs, personalize your protocols, track your progress, and offer advice.

Hear from our patients

Amazing effect on my mental clarity

The methylene blue has had an amazing effect on my mental clarity and focus and the ability to recall and put my thoughts together and my energy level is greater now too! Literally I’ve had overall just a sense of better well being.

James J

Remarkable Results in Just 3 Days

I just wanted to share how incredibly impressed I am with your methylene blue supplement. I’ve been taking a dose of approximately 16 mg, and within just three days, I’ve noticed a truly remarkable shift in my body.

Simon Levy

Great products!

Very happy with my experience, the methylene blue especially helps a ton with my adhd and ability to focus, looking forward to more products coming out in the future.

Brent Lindstrom

This stuff works!

I have been using the Oxytocin nasal spray for the last 3 months and definitely notice a difference in my mood, my joint aches/pains and I find I feel more relaxed day to day.

Dori T

Just wow

I’m ramping up my intranasal oxytocin protocol and I can’t believe the improvement it’s already making. I suffer from various conditions, and it’s making an impact on most of them. My pain, stress, and anxiety have taken a nosedive.

Ned Drummond

Healthspan provides great care

Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring. My lab review was thorough and insightful, reflecting the clinic’s commitment to personalized, data-driven longevity care.

Juan

Go for the consultation if you have any doubts, bc you wont after!

Informative, professional, supportive, with an exceptional scope of knowledge. In a word, excellent.

Leslie D

Healthspan continues to be cutting edge

Healthspan continues to be cutting edge with regard to health and longevity.

Jim W

Frozen shoulder gone for the first time

I had frozen shoulder that never went away. I finally have relief. They identified some biomarkers that we wanted to optimize and some other health goals to target. I have never had anyone spend so much time working with me individually.

Dave L

I am very impressed

I am very impressed with the amount of information I was provided during my lab consult. After today's consult I have a comprehensive get well plan and a clear understanding of what my results mean

John R

Grateful for Healthspan

Grateful for Healthspan! The most knowledgeable team. Helped me evaluate my labs and put together a plan to start optimizing things. I wish my current doctors were this thorough.

Danny

Great Service

Great service - they provide more guidance in 30 minutes virtually than I get in 6 months from my family doc.

Joseph C

Reviews

4.9/5

127 reviews

blanchards

Healthspan is amazing!!!

Kristen was fantastic …she was kind, informative and professional. She helped me in my journey to Health and longevity! Thank you!!

Jim White

Healthspan continues to be cutting edge

Healthspan continues to be cutting edge with regard to health and longevity. Brandon was knowledgeable and supportive. The details of the study were explained well and in detail.

Anthony Badillo

Great experience with Healthspan

I’ve had a great experience with Healthspan. All of the representatives have been extremely responsive when sending messages on the portal, and I had a great call reviewing my initial labs with Brandon Fell who was extremely knowledgeable and courteous. I’ve started the Rapamycin and Acarbose protocol, and I’m looking forward to seeing what my updated labs will show in a couple months!

We study the studies

Healthspan longevity experts continuously review the latest clinical research, curating results to help deepen your understanding of aging science.

06 / 13 / 202506/13/2514 MIN READ
How Stress Alters DNA Methylation to Accelerate Biological Age — and How Oxytocin May Modulate This Epigenetic Pathway
11 / 09 / 202411/09/2425 MIN READ
Oxytocin: The Unexpected Neuroprotective Molecule Targeting Brain Aging and Enhancing Cognitive Health
05 / 03 / 202505/03/2534 MIN READ
Methylene Blue for the Aging Brain: Mitochondrial Mechanisms Driving Neuroprotective and Cognitive Benefits
08 / 05 / 202308/05/2320 MIN READ
Endorphins and Anti-Inflammation: A Review of Low-Dose Naltrexone's (LDN) Potential in Extending Healthspan and Treating Chronic Diseases

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