The Role of Inflammation in Healthspan

The Science of

(Autoimmunity)

Inflammatory Signaling

Mitochondrial Dysfunction

Energy Metabolism

The Science

 

Autoimmune conditions arise when inflammation spreads throughout the body. Overactive immune signals, stressed mitochondria, and disrupted energy metabolism combine to drive fatigue, tissue damage, and faster aging. Restoring immune balance and cellular energy can calm inflammation, protect organs, and improve overall health and performance.

Cellular drivers of autoimmune decline and longevity

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Immune DysregulationIn autoimmune conditions, the immune system shifts into a chronically imbalanced state. It may remain overactive after infection or begin misidentifying healthy tissue as a threat. This miscalibration drives inappropriate immune responses that damage organs, joints, or nerves and prolong symptoms.
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Mitochondrial DysfunctionAutoimmune activity and chronic inflammation impair mitochondrial efficiency, limiting the cell’s ability to generate energy. The result is fatigue, muscle weakness, and cognitive fog, which are features common to both autoimmune disease and post-viral syndromes.
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Persistent InflammationWhen inflammation fails to resolve, it becomes a driver of ongoing damage. In autoimmune disease, this low-grade but relentless inflammation underlies symptoms such as pain, stiffness, and slowed recovery while also accelerating tissue breakdown and aging processes.

Interventions can help

Restoring Mitochondrial Health

Mitochondrial support from methylene blue, AMPK activators, and urolithin A boosts energy production and reduces oxidative stress. Restoring mitochondrial function helps ease fatigue, brain fog, and muscle weakness in autoimmune and post-viral syndromes.

Recalibrate Immune Responses

Targeted therapies such as rapamycin and LDN help quiet overactive immune pathways while strengthening regulatory mechanisms. By restoring balance, these interventions reduce tissue-damaging responses that fuel autoimmune conditions.

Resolve Chronic Inflammation

Persistent low-grade inflammation, driven by senescent cells and impaired autophagy, accelerates tissue breakdown. Rapamycin, LDN, and AMPK activators reduce inflammation, enhance clearance, and protect organ health.

Recalibrate Immune Responses

Targeted therapies such as rapamycin and LDN help quiet overactive immune pathways while strengthening regulatory mechanisms. By restoring balance, these interventions reduce tissue-damaging responses that fuel autoimmune conditions.

Restoring Mitochondrial Health

Mitochondrial support from methylene blue, AMPK activators, and urolithin A boosts energy production and reduces oxidative stress. Restoring mitochondrial function helps ease fatigue, brain fog, and muscle weakness in autoimmune and post-viral syndromes.

Resolve Chronic Inflammation

Persistent low-grade inflammation, driven by senescent cells and impaired autophagy, accelerates tissue breakdown. Rapamycin, LDN, and AMPK activators reduce inflammation, enhance clearance, and protect organ health.

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How It Works

Hear from our patients

All around 5 stars.

Prominent effects were obvious only a couple days in, and the autophagy blend has acute effects within minutes of taking it regarding pain/inflammation.

Cody C

My joint pain has got 
so much better.

I really appreciate how they review blood work with me and guide me through the process. My joint pain has got so much better. I am glad that they have figured a way to make Rapamycin more available

Stephanie

Nothing short of miraculous...

Osteoarthritis pains improved 97%, pain 
in my neck is gone! All this and Ive just entered week 4 of treatment with Rapamycin. Can hardly wait for week 8 to see how much more Ill be amazed!!

Paul Windhausen

Frozen shoulder gone for the first time

I had frozen shoulder that never went away. I finally have relief. They identified some biomarkers that we wanted to optimize and some other health goals to target. I have never had anyone spend so much time working with me individually.

Dave L

The right balance

I’m really liking the thoroughness and ease of getting rapamycin from Healthspan. Right down to the labs and the live consultation. For me, it’s the right balance of self-serve, research-driven guidance, and a bit of personalization.

Brooks Jordan

My trusted partner for health and longevity

Since starting their research-backed, patient-centric protocols, I have more energy, less pain, and improved blood biomarkers especially around metabolic health.

Hiro Takata

Healthspan provides great care

Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring. My lab review was thorough and insightful, reflecting the clinic’s commitment to personalized, data-driven longevity care.

Juan

Great products!

Very happy with my experience, the methylene blue especially helps a ton with my adhd and ability to focus, looking forward to more products coming out in the future.

Brent Lindstrom

Healthspan continues to be cutting edge

Healthspan continues to be cutting edge with regard to health and longevity.

Jim W

Amazing effect on my mental clarity

The methylene blue has had an amazing effect on my mental clarity and focus and the ability to recall and put my thoughts together and my energy level is greater now too! Literally I’ve had overall just a sense of better well being.

James J

I am very impressed

I am very impressed with the amount of information I was provided during my lab consult. After today's consult I have a comprehensive get well plan and a clear understanding of what my results mean

John R

Grateful for Healthspan

Grateful for Healthspan! The most knowledgeable team. Helped me evaluate my labs and put together a plan to start optimizing things. I wish my current doctors were this thorough.

Danny

Great Service

Great service - they provide more guidance in 30 minutes virtually than I get in 6 months from my family doc.

Joseph C

This stuff works!

I have been using the Oxytocin nasal spray for the last 3 months and definitely notice a difference in my mood, my joint aches/pains and I find I feel more relaxed day to day.

Dori T

Go for the consultation if you have any doubts, bc you wont after!

Informative, professional, supportive, with an exceptional scope of knowledge. In a word, excellent.

Leslie D

Love all protocols suggested by Healthspan

Love all protocols suggested by healthspan. I have found their anti-inflamatory angle very helpful with recovery and some inflamation issues I have had for several years. 5 stars

Chris S

Just wow

I’m ramping up my intranasal oxytocin protocol and I can’t believe the improvement it’s already making. I suffer from various conditions, and it’s making an impact on most of them. My pain, stress, and anxiety have taken a nosedive.

Ned Drummond

Remarkable Results in Just 3 Days

I just wanted to share how incredibly impressed I am with your methylene blue supplement. I’ve been taking a dose of approximately 16 mg, and within just three days, I’ve noticed a truly remarkable shift in my body.

Simon Levy

(Featured In)

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Ahead of the field

I would say that rapamycin is the current best-in-class for a longevity drug

Rapamycin... is at the leading edge of a generation of research trials.

I would say that rapamycin is the current best-in-class for a longevity drug

Rapamycin... is at the leading edge of a generation of research trials.

I would say that rapamycin is the current best-in-class for a longevity drug

Rapamycin... is at the leading edge of a generation of research trials.

I would say that rapamycin is the current best-in-class for a longevity drug

Rapamycin... is at the leading edge of a generation of research trials.

We study the studies

Healthspan longevity experts continuously review the latest clinical research, curating results to help deepen your understanding of aging science.

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