Metabolic
Metformin
A fasting mimetic that targets multiple longevity pathways, optimizes metabolic health, and increases autophagy.
Metabolic
Metabolic
Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome.
Starting at $27 /mo
By testing for bioavailability, we're able to deliver medications that are more easily absorbed by your body, leading to improved outcomes and better overall health.
Our US-based clinicians are here to provide the guidance and support you need to achieve your health and longevity goals, and to address any concerns or questions you may have.
All of our medications are pharmaceutical-grade and dispensed by a licensed pharmacist. We have extensively tested all of the formulations of our medications to offer our patients the highest biovailable medications.
A fasting mimetic that targets multiple longevity pathways, optimizes metabolic health, and increases autophagy.
Metformin effectively stimulates longevity pathways within the body, promoting overall well-being and potentially extending healthspan.
Metformin has been shown to significantly decrease insulin resistance, helping to regulate blood sugar levels and potentially preventing the onset of type 2 diabetes.
By reducing chronic inflammation in the body, metformin can help counteract the effects of inflammaging, which is associated with various age-related diseases and conditions.
Metformin has the potential to increase NAD+ levels, a coenzyme involved in energy metabolism and cellular repair processes, contributing to improved cellular health and function.
Insulin/IGF-1 Signaling Pathway
AMP-activated Protein Kinase (AMPK) Activation
mTOR Pathway
Autophagy
Metabolic Regulation
Inflammation
Cellular Senescence
Oxidative Stress
Over time, our cells can become less responsive to insulin, a hormone crucial for regulating our blood sugar. It takes more and more insulin to transport glucose into a cell.
This increase in insulin corresponds with an increase in the hormone IGF-1, a growth hormone that stimulates cell growth.
As we age, the insulin/IGF-1 pathway may become overactive. The increased presence of IGF-1 can lead to abnormal cell growth and proliferation of both cancer cells and senescent cells.
Some scientific studies suggest that when IGF-1 activity is turned down a notch, it can lead to a longer, healthier life.
Metformin enhances our cells' response to insulin and turns down IGF-1 activity. This means a healthier metabolism and a reduced risk of conditions like type 2 diabetes. By fine-tuning cellular pathways linked to insulin and aging metformin improves healthspan.
Cancer Mortality
Cancer Incidence
Cardiovascular Disease
Alzheimer
Metformin
The science
SUPPORT
Healthspan will only recommend treatments with robust clinical data to support its use. Our clinical team is here to help you find the right protocol to meet your health goals.
Energy
Thank you for your exemplary service making my experience with Healthspan outstanding.
Senescence
The staff at healthspan is the most responsive and informative group I have ever worked with! Thanks for all your help,
Metformin primarily works by reducing the amount of glucose produced by the liver and enhancing the sensitivity of muscle cells to insulin. This helps your body to better manage blood sugar levels, which in turn, can have long-term health benefits.
Metformin primarily works by reducing the amount of glucose produced by the liver and enhancing the sensitivity of muscle cells to insulin. This helps your body to better manage blood sugar levels, which in turn, can have long-term health benefits.
Your Healthspan assigned clinical team will review your medical history and biomarkers to make a recommendation for your metformin dosing protocol. The typical longevity dose can range from 500 to 1000 mg per day.
Your Healthspan assigned clinical team will review your medical history and biomarkers to make a recommendation for your metformin dosing protocol. The typical longevity dose can range from 500 to 1000 mg per day.
In general, metformin is considered safe for long-term use in managing diabetes. However, its long-term use for non-diabetic individuals for longevity purposes is still being researched. Regular check-ups are recommended to monitor for potential side effects.
In general, metformin is considered safe for long-term use in managing diabetes. However, its long-term use for non-diabetic individuals for longevity purposes is still being researched. Regular check-ups are recommended to monitor for potential side effects.
The risk of significant lactic acidosis associated with metformin is extremely rare when the medication is taken at appropriate doses and when the kidneys are functioning properly. However, as a precautionary measure, we recommend that patients discontinue metformin usage at least 3 days prior to undergoing any medical procedure or imaging that involves the use of contrast agents, such as a CT scan.
The risk of significant lactic acidosis associated with metformin is extremely rare when the medication is taken at appropriate doses and when the kidneys are functioning properly. However, as a precautionary measure, we recommend that patients discontinue metformin usage at least 3 days prior to undergoing any medical procedure or imaging that involves the use of contrast agents, such as a CT scan.
Metformin is generally not known to cause dangerously low levels of blood sugar. However, it's important to note that individuals have varying tolerances for lower blood sugar levels. Therefore, some patients taking metformin may experience symptoms of low blood sugar, such as lightheadedness, nausea, or fatigue.
To minimize the risk of experiencing these symptoms, it is recommended to start metformin at a low dose and gradually increase it over time. This approach allows your body to adjust to the medication and helps mitigate the likelihood of blood sugar dropping too low.
Based on our experience, we have observed that most patients with a history of hypoglycemia can tolerate lower doses of metformin, typically starting at 500mg per day. However, it's essential to work closely with your healthcare provider to determine the most appropriate dosage for your specific needs.
By monitoring your blood sugar levels regularly and maintaining open communication with your healthcare team, you can ensure that metformin is effectively managing your blood sugar without causing it to drop to unsafe levels.
Metformin is generally not known to cause dangerously low levels of blood sugar. However, it's important to note that individuals have varying tolerances for lower blood sugar levels. Therefore, some patients taking metformin may experience symptoms of low blood sugar, such as lightheadedness, nausea, or fatigue.
To minimize the risk of experiencing these symptoms, it is recommended to start metformin at a low dose and gradually increase it over time. This approach allows your body to adjust to the medication and helps mitigate the likelihood of blood sugar dropping too low.
Based on our experience, we have observed that most patients with a history of hypoglycemia can tolerate lower doses of metformin, typically starting at 500mg per day. However, it's essential to work closely with your healthcare provider to determine the most appropriate dosage for your specific needs.
By monitoring your blood sugar levels regularly and maintaining open communication with your healthcare team, you can ensure that metformin is effectively managing your blood sugar without causing it to drop to unsafe levels.
At Healthspan, we employ comprehensive methods to measure the effectiveness of our metformin protocol. We prioritize your well-being by conducting regular lab work that assesses your response to metformin. Our approach involves analyzing a range of biomarkers specifically associated with longevity, allowing us to gain valuable insights into the impact of metformin on your health.
One of the primary indicators we focus on is blood sugar levels. Patients taking metformin typically experience significant improvements in their ability to manage blood sugar, leading to better overall glycemic control. By tracking and monitoring these levels through lab testing, Healthspan can determine the effectiveness of metformin in this crucial aspect.
Moreover, we understand that evaluating your biological age is equally important. To provide a holistic assessment, we offer biological age testing, which allows you to compare your biological age with your chronological age. This unique feature enables you to gauge whether metformin is potentially slowing down your biological aging process in relation to your chronological aging.
Through our regular lab work and additional biological age testing, Healthspan ensures a thorough evaluation of the metformin protocol's impact on your health, allowing us to tailor our approach and support your well-being effectively.
At Healthspan, we employ comprehensive methods to measure the effectiveness of our metformin protocol. We prioritize your well-being by conducting regular lab work that assesses your response to metformin. Our approach involves analyzing a range of biomarkers specifically associated with longevity, allowing us to gain valuable insights into the impact of metformin on your health.
One of the primary indicators we focus on is blood sugar levels. Patients taking metformin typically experience significant improvements in their ability to manage blood sugar, leading to better overall glycemic control. By tracking and monitoring these levels through lab testing, Healthspan can determine the effectiveness of metformin in this crucial aspect.
Moreover, we understand that evaluating your biological age is equally important. To provide a holistic assessment, we offer biological age testing, which allows you to compare your biological age with your chronological age. This unique feature enables you to gauge whether metformin is potentially slowing down your biological aging process in relation to your chronological aging.
Through our regular lab work and additional biological age testing, Healthspan ensures a thorough evaluation of the metformin protocol's impact on your health, allowing us to tailor our approach and support your well-being effectively.
Our Metformin tablets meet stringent quality standards, similar to all pharmaceuticals sold within the United States, ensuring their safety and efficacy. While generic medications like Metformin might be sourced globally, it's important to note that regardless of their origin, all our medicines are dispensed and shipped from a U.S. based pharmacy that is registered and subject to routine inspections by the FDA. We prioritize your health and safety. As such, every medication you receive, including Metformin, has undergone rigorous manufacturing protocols and stringent approval processes. These standards align with those followed by national pharmacies, such as Walgreens and CVS, ensuring that the medications you receive from us are of the highest quality, regardless of their origin. We believe in transparency and are more than willing to provide further information about the manufacturing and dispensing processes of our products. Should you have any questions or need more information, our team is readily available to assist you.
Our Metformin tablets meet stringent quality standards, similar to all pharmaceuticals sold within the United States, ensuring their safety and efficacy. While generic medications like Metformin might be sourced globally, it's important to note that regardless of their origin, all our medicines are dispensed and shipped from a U.S. based pharmacy that is registered and subject to routine inspections by the FDA. We prioritize your health and safety. As such, every medication you receive, including Metformin, has undergone rigorous manufacturing protocols and stringent approval processes. These standards align with those followed by national pharmacies, such as Walgreens and CVS, ensuring that the medications you receive from us are of the highest quality, regardless of their origin. We believe in transparency and are more than willing to provide further information about the manufacturing and dispensing processes of our products. Should you have any questions or need more information, our team is readily available to assist you.
A healthy lifestyle is recommended while taking metformin. This includes a balanced diet, regular exercise, adequate sleep, and reducing stress. These behaviors complement the potential longevity benefits of metformin.
A healthy lifestyle is recommended while taking metformin. This includes a balanced diet, regular exercise, adequate sleep, and reducing stress. These behaviors complement the potential longevity benefits of metformin.
Metformin has a very high safety profile. There is over 60 years of data that demonstrates its high safety profile and therapeutic value. Your Healthspan physician will review your health history and current medications to see if metformin is appropriate for you.
Metformin has a very high safety profile. There is over 60 years of data that demonstrates its high safety profile and therapeutic value. Your Healthspan physician will review your health history and current medications to see if metformin is appropriate for you.
Metformin can cause side effects, including digestive issues like nausea, vomiting, stomach upset, diarrhea, and a metallic taste in the mouth. Less common, but more serious side effects can include lactic acidosis, particularly in those with kidney issues.
Metformin can cause side effects, including digestive issues like nausea, vomiting, stomach upset, diarrhea, and a metallic taste in the mouth. Less common, but more serious side effects can include lactic acidosis, particularly in those with kidney issues.
Sign up for The Longevity Blueprint, a weekly newsletter from Healthspan analyzing the latest longevity research.