At Healthspan, we are committed to ensuring the effectiveness of the medications we prescribe. This commitment extends to addressing the challenges of bioavailability, which can notably impact the usage and efficiency of certain drugs, including rapamycin. To tackle this, we employ a robust testing program to select the formulations and brands of rapamycin that offer the best absorption levels.

Bioavailability is a key pharmacokinetic parameter that quantifies the percentage of the administered drug dose that successfully reaches systemic circulation and becomes available to exert its therapeutic effect. It’s a measure of the rate and extent of a drug's absorption.

In assessing the bioavailability of our medications, we measure two critical pharmacokinetic parameters: Cmax and Tmax.

Cmax, or 'maximum concentration,' signifies the highest concentration a drug achieves in the body following administration and prior to the introduction of a second dose.

Tmax, or 'time to maximum concentration,' denotes the duration it takes for a drug to reach its Cmax post-administration, providing a measure of the drug's absorption rate.

We believe in personalized care and thus, offer our patients the option to test their individual rapamycin levels. This enables us to understand each patient's unique absorption profile of the medication, taking into account the variability of their biology. This approach ensures that our patients receive the most effective therapeutic regimen tailored to their individual needs.

The Rapamycin Protocol is a fully comprehensive and personalized treatment plan guided by your Healthspan physician, medical team, and the Healthspan Research Review team.

• Medical review by a US-based functional medicine doctor. Our US functional medicine doctors analyze your biomarkers and clinical data to prescribe personalized health recommendations. If your doctor deems the medication appropriate for you, you will be prescribed a treatment plan explaining the benefits and what to expect. Your doctor will review & optimize your dosage every 30 days.

• Prescriptions delivered to your door. Our US-based pharmacies, which are LegitScript-certified, handle the direct shipment of your medication to your doorstep. We prioritize selecting medications with the highest bioavailability to maximize their effectiveness. Additionally, we provide patients with the option to test the concentrations of Sirolimus in their bloodstream, ensuring that the treatment is suitable and personalized for their specific needs.

• Regular Lab Testing for continual optimization of your rapamycin protocol. We will optimize your dosing regimen by taking baseline blood draw to monitor biomarkers key to longevity and follow up with subsequent lab testing to see how your treatment is progressing and further optimize your treatment plan.

• The Healthspan Research Review Team. Healthspan collaborates closely with esteemed researchers to conduct a meticulous meta-analysis of the most cutting-edge studies in the field of longevity medicine. This ensures that our protocol is based on the latest scientific findings. They are available to address any health-related inquiries you may have and offer an in-depth analysis of the most recent research pertaining to your specific concerns. This personalized approach allows us to provide you with tailored information and insights to support your well-being effectively.

Upon thorough medical review and screening, should you be deemed suitable for the Healthspan Rapamycin Protocol, your administration of Rapamycin will occur just once a week. For instance, should your current weekly dosage be 5mg, and you're given 1mg pills, you'll consume all five pills on a single day, as opposed to distributing them over the week. You'll then rest until the next week.

The reason for this methodology stems from the cyclical nature of the benefits Rapamycin offers for anti-aging. Unlike transplant patients who take Rapamycin daily, the longevity benefits are drawn from the intermittent inhibition of mTOR. The therapeutic benefit of Rapamycin is derived from pulsated inhibition of mTOR, avoiding continuous inhibition. This approach prevents bloodstream concentrations of rapamycin that could inhibit mTOR-Complex 2, leading to immune suppression, which we aim to evade.

By adhering to a weekly dosage, adjusted according to your unique biomarkers and phenotype, we sidestep the immunosuppressive side effects of Rapamycin. We strive to administer Rapamycin in a manner that leverages the mTOR inhibitory benefits, such as stimulating autophagy, in cycles, and then returning to baseline mTOR activity.

At Healthspan, we harness the power of advanced technology and your unique biomarkers to craft a tailored Rapamycin dosage plan just for you. Typically, we initiate a patient's treatment with a weekly dose of 3mg, carefully escalating this over time to reach the optimum dosage, which generally lies between 5 to 8mg per week. Please note, the provision of medication is strictly contingent upon a comprehensive medical review and initial screening process.

No, rapamycin cannot be purchased as an over-the-counter supplement. As a potent pharmaceutical, rapamycin is regulated by the FDA and requires a doctor's prescription for use. Due to its effects, it must be administered under careful medical supervision. Developed by leading longevity experts, the Healthspan protocol incorporates advanced biomarker testing to ensure safe administration and maximize the benefits to our patients.

For your convenience, rapamycin in our Healthspan protocol is delivered directly to your doorstep. This ensures not only ease of access but also guarantees you receive a formulation with the highest bioavailability, tailored to your health profile. Our process bypasses traditional retail channels, providing you with a seamless and efficient experience from prescription to delivery.

Yes, Healthspan can prescribe compounded rapamycin in cases where it may be necessary, but we prioritize generic formulations due to their superior clinical efficacy. Many digital health companies prescribe compounded rapamycin because it is a cheaper option; however, this formulation often lacks clinical effectiveness for most patients because of its significantly lower absorption.

At Healthspan, our priority is to ensure patients receive the most effective treatment, which is why we emphasize prescribing generic over compounded formulations of rapamycin. Generic rapamycin offers several key advantages:

• Higher Bioavailability: Generic rapamycin has a significantly higher bioavailability compared to compounded versions. The Harinath et al. (2024) study revealed that generic formulations provide a threefold increase in bioavailability (0.87 vs. 0.25 ng/mL per mg), ensuring patients receive the full therapeutic benefit of rapamycin.

• Predictable Dosing: With consistent absorption, generic formulations allow for more predictable dosing and treatment outcomes.

• Cost-Effectiveness: Although compounded rapamycin may appear to be a less expensive option, its minimal absorption often requires higher doses to achieve similar effects, ultimately making it less cost-effective.

• Rigorous Quality Assurance: Generic rapamycin undergoes strict quality assurance measures, providing a level of reliability that compounded formulations cannot consistently match.

To further support individualized care, Healthspan offers a bioavailability measurement lab, enabling precise adjustments and tracking of therapeutic effectiveness for each patient. This ensures that our patients can achieve optimal results with the highest level of safety and effectiveness.