Rapamycin
One of the most comprehensive longevity interventions available, Rapamycin addresses several molecular processes at once to slow the aging process and promote cellular health.
By testing for bioavailability, we're able to deliver medications that are more easily absorbed by your body, leading to improved outcomes and better overall health.
Our US-based clinicians are here to provide the guidance and support you need to achieve your health and longevity goals, and to address any concerns or questions you may have.
All medications are pharmaceutical-grade, dispensed by licensed pharmacists, and tested to deliver the highest bioavailability.
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Ahead of the field
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
Our patients see an average reduction in biological age of
8 years
Go beneath the surface of aging
Activating autophagy
Rapamycin inhibits the mTOR pathway to trigger autophagy, a natural process for removing damaged cellular material. Aiding autophagy enhances tissue regeneration and supports healthy aging.
Reducing senescence
Rapamycin inhibits mTOR to slow the accumulation of senescent cells that release inflammatory signals and damage surrounding tissues, helping preserve tissue function and reduce age-related decline.
Enhancing mitochondria
Rapamycin activates mitophagy to clear damaged mitochondria while promoting the generation of new, healthy ones, improving cellular energy production and supporting optimal function across vital organs.
Protecting brain function
Rapamycin targets neuroinflammation, protein misfolding, and mitochondrial dysfunction to preserve cognitive performance and reduce risk of age-related neurodegeneration, when started early.
Reducing inflammation
Rapamycin reduces chronic, low-grade inflammation that accelerates aging and tissue damage, helping preserve organ function and extend the years of healthy, active living.
Reducing cancer risk
Rapamycin may help reduce tumorigenic potential by acting as a molecular brake on cellular overgrowth and reducing inflammatory signals associated with increased cancer risk, though outcomes may vary.
Dosing is everything
The highest quality, made for you
Rapamycin only works if it’s absorbed. That’s why our protocol relies on FDA-approved, enteric-coated tablets designed to withstand stomach acid and release rapamycin in the intestine for reliable bioavailability. This avoids the instability and poor absorption often seen with compounded capsules or raw powder.
Consistency matters at every dose. Each prescription is personalized by a U.S.-licensed physician, with the option of a Sirolimus blood panel to directly measure absorption and confirm therapeutic levels. This ensures your protocol is safe, effective, and tailored to your biology.
Our rapamycin is sourced only from FDA-approved manufacturers and dispensed through NABP-accredited U.S. pharmacies. Every batch is tested under USP standards for identity, strength, and purity—eliminating the risks associated with unregulated or international sources.
While our protocol is built on FDA-approved generics for their proven absorption, we understand some patients may prefer compounded rapamycin. In these cases, we provide access to trusted compounding pharmacies with complimentary bioavailability testing. This ensures absorption is confirmed and dosing can be adjusted to the same high standard of safety and effectiveness.
Going Deeper
Cellular pathways are roads to peak performance
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Included with your Rapamycin Protocol
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Hear from our patients
Nothing short of miraculous...
Osteoarthritis pains improved 97%, pain in my neck is gone! All this and Ive just entered week 4 of treatment with Rapamycin. Can hardly wait for week 8 to see how much more Ill be amazed!!
Paul Windhausen
My joint pain has got so much better.
I really appreciate how they review blood work with me and guide me through the process. My joint pain has got so much better. I am glad that they have figured a way to make Rapamycin more available
Stephanie
Labs, progress, and care. All dialed in.
Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring
Jspflorida
Reviews
129 reviews
Frequently asked questions
The Rapamycin Protocol is a personalized treatment plan guided by your Healthspan physician and clinical team. Our US functional medicine doctors analyze your biomarkers and clinical data to prescribe personalized health recommendations. If your doctor deems the medication appropriate for you, you will be prescribed a treatment plan explaining the benefits and what to expect. Your doctor will review & optimize your dosage every 30 days. Prescriptions are shipped directly from LegitScript-certified US pharmacies, with the option to test sirolimus concentrations for added precision. Baseline and follow-up lab testing track key longevity biomarkers, ensuring your protocol is continually optimized for long-term health.
At Healthspan, we are committed to ensuring the effectiveness of every medication we prescribe, which includes addressing the critical challenge of bioavailability—how well a drug is absorbed and utilized by the body. To optimize rapamycin treatment, we rigorously test and select formulations with the best absorption profiles, guided by key pharmacokinetic measures such as Cmax (the maximum concentration of the drug in the body) and Tmax (the time it takes to reach that concentration). We also offer patients the option to test their own rapamycin levels, allowing us to account for individual variability in absorption and tailor dosing more precisely. This personalized approach ensures that each patient receives the most effective therapeutic regimen for their unique biology.
We have carefully selected each biomarker below to provide you with the broadest and deepest understanding of your ever-changing health. The following biomarkers are included with your panel. The Rapamycin Protocol Panel offers a comprehensive health assessment, integrating a complete metabolic profile, complete blood count (CBC), lipid panel, Hemoglobin A1C (HbA1C), and High-sensitivity C-reactive protein (Hs-CRP) tests. This panel is designed to deliver a comprehensive view of your health, focusing on key aspects such as metabolic efficiency, blood health, cardiovascular risk, and systemic inflammation. By utilizing advanced algorithms, the panel goes beyond traditional assessments to calculate your biological age, providing a deeper insight into your body's aging process in comparison to your chronological age. This analysis is crucial in identifying potential health risks and areas for improvement, guiding you towards a personalized pathway for optimizing your longevity and maintaining a robust metabolic engine.
Yes, Healthspan can prescribe compounded rapamycin when necessary, but we prioritize generic formulations because they offer superior clinical efficacy and absorption. Research shows that generic rapamycin has threefold higher bioavailability compared to compounded versions, leading to more predictable dosing and reliable therapeutic outcomes. While compounded options may seem cheaper, their poor absorption often makes them less effective and ultimately less cost-efficient. To further individualize care, we also offer lab testing to measure bioavailability, allowing us to tailor dosing and ensure patients achieve the safest and most effective results.
At Healthspan, we harness the power of advanced technology and your unique biomarkers to craft a tailored Rapamycin dosage plan just for you. Typically, we initiate a patient's treatment with a weekly dose of 3mg, carefully escalating this over time to reach the optimum dosage, which generally lies between 5 to 8mg per week. Please note, the provision of medication is strictly contingent upon a comprehensive medical review and initial screening process.
If you are deemed suitable for the Healthspan Rapamycin Protocol, your medication will be taken once weekly rather than daily. This pulsed dosing strategy is designed to harness the anti-aging benefits of intermittent mTOR inhibition while avoiding the continuous suppression that transplant patients require, which can carry immune risks. By spacing doses weekly, we prevent the sustained blood levels that could inhibit mTOR-Complex 2 and lead to unwanted immunosuppressive effects. Your exact dosage is personalized to your biomarkers and phenotype, ensuring the benefits of autophagy and cellular renewal are achieved safely and effectively.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
No, rapamycin cannot be purchased as an over-the-counter supplement. As a potent pharmaceutical, rapamycin is regulated by the FDA and requires a doctor's prescription for use. Due to its effects, it must be administered under careful medical supervision. Developed by leading longevity experts, the Healthspan protocol incorporates advanced biomarker testing to ensure safe administration and maximize the benefits to our patients.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.
The Rapamycin Protocol is a personalized treatment plan guided by your Healthspan physician and clinical team. Our US functional medicine doctors analyze your biomarkers and clinical data to prescribe personalized health recommendations. If your doctor deems the medication appropriate for you, you will be prescribed a treatment plan explaining the benefits and what to expect. Your doctor will review & optimize your dosage every 30 days. Prescriptions are shipped directly from LegitScript-certified US pharmacies, with the option to test sirolimus concentrations for added precision. Baseline and follow-up lab testing track key longevity biomarkers, ensuring your protocol is continually optimized for long-term health.
At Healthspan, we are committed to ensuring the effectiveness of every medication we prescribe, which includes addressing the critical challenge of bioavailability—how well a drug is absorbed and utilized by the body. To optimize rapamycin treatment, we rigorously test and select formulations with the best absorption profiles, guided by key pharmacokinetic measures such as Cmax (the maximum concentration of the drug in the body) and Tmax (the time it takes to reach that concentration). We also offer patients the option to test their own rapamycin levels, allowing us to account for individual variability in absorption and tailor dosing more precisely. This personalized approach ensures that each patient receives the most effective therapeutic regimen for their unique biology.
We have carefully selected each biomarker below to provide you with the broadest and deepest understanding of your ever-changing health. The following biomarkers are included with your panel. The Rapamycin Protocol Panel offers a comprehensive health assessment, integrating a complete metabolic profile, complete blood count (CBC), lipid panel, Hemoglobin A1C (HbA1C), and High-sensitivity C-reactive protein (Hs-CRP) tests. This panel is designed to deliver a comprehensive view of your health, focusing on key aspects such as metabolic efficiency, blood health, cardiovascular risk, and systemic inflammation. By utilizing advanced algorithms, the panel goes beyond traditional assessments to calculate your biological age, providing a deeper insight into your body's aging process in comparison to your chronological age. This analysis is crucial in identifying potential health risks and areas for improvement, guiding you towards a personalized pathway for optimizing your longevity and maintaining a robust metabolic engine.
Yes, Healthspan can prescribe compounded rapamycin when necessary, but we prioritize generic formulations because they offer superior clinical efficacy and absorption. Research shows that generic rapamycin has threefold higher bioavailability compared to compounded versions, leading to more predictable dosing and reliable therapeutic outcomes. While compounded options may seem cheaper, their poor absorption often makes them less effective and ultimately less cost-efficient. To further individualize care, we also offer lab testing to measure bioavailability, allowing us to tailor dosing and ensure patients achieve the safest and most effective results.
At Healthspan, we harness the power of advanced technology and your unique biomarkers to craft a tailored Rapamycin dosage plan just for you. Typically, we initiate a patient's treatment with a weekly dose of 3mg, carefully escalating this over time to reach the optimum dosage, which generally lies between 5 to 8mg per week. Please note, the provision of medication is strictly contingent upon a comprehensive medical review and initial screening process.
If you are deemed suitable for the Healthspan Rapamycin Protocol, your medication will be taken once weekly rather than daily. This pulsed dosing strategy is designed to harness the anti-aging benefits of intermittent mTOR inhibition while avoiding the continuous suppression that transplant patients require, which can carry immune risks. By spacing doses weekly, we prevent the sustained blood levels that could inhibit mTOR-Complex 2 and lead to unwanted immunosuppressive effects. Your exact dosage is personalized to your biomarkers and phenotype, ensuring the benefits of autophagy and cellular renewal are achieved safely and effectively.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
No, rapamycin cannot be purchased as an over-the-counter supplement. As a potent pharmaceutical, rapamycin is regulated by the FDA and requires a doctor's prescription for use. Due to its effects, it must be administered under careful medical supervision. Developed by leading longevity experts, the Healthspan protocol incorporates advanced biomarker testing to ensure safe administration and maximize the benefits to our patients.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.