Topical Rapamycin for Skin
An advanced treatment for targeting skin cell senescence — a root driver of wrinkles, thinning, and loss of elasticity — to restore firmness, smooth fine lines, and repair visible damage.
Visibly reduces wrinkles and restores elasticity by slowing the buildup of aging cells, helping skin look stronger, lifted, and more youthful.
Softens signs of photoaging by rebuilding collagen and improving resilience.
Targets the cellular drivers of aging to preserve youthful texture and glow.
Transform your skin from within
Targeting senescence
Rapamycin reduces visible skin aging by clearing senescent cells and suppressing systemic inflammation. Creating a healthier skin environment can lead to smoother, firmer skin over time.
Modulating mTOR
Topical Rapamycin for Skin modulates the mTOR pathway to restore collagen production, helping improve elasticity, improve firmness, and reduce wrinkles linked to aging and UV damage.
Activating skin autophagy
Promotes skin renewal by activating autophagy, the body’s natural process for clearing dead cells and cellular debris, which supports healthier skin texture, tone, and a more radiant appearance.
Support Emotional Balance
Regulates dopamine and serotonin pathways to improve mood, stress response, and cognitive motivation.
Increase Brain Adaptability
Enhances neuroplasticity by restoring mitochondrial efficiency and supporting synaptic health under stress.
Optimize Gut–Brain Axis
Improves vagal tone and immune-neural signaling through mitochondrial-immune interactions, enhancing systemic resilience.
The highest standards of care
Purity is measured to confirm that nearly all of the material is the active compound. At around 99.5% purity, pharmaceutical-grade rapamycin avoids contaminants or inactive byproducts that could reduce effectiveness or increase the risk of irritation when applied to the skin.
Potency is verified every 3–6 months to confirm each batch remains within ±10% of the intended concentration. For rapamycin, precise dosing is essential—too little may limit its ability to reduce skin senescence, while too much may raise the risk of unwanted effects. Consistent potency ensures reliable results with each application.
Trace metal testing ensures ingredients remain free from unsafe levels of arsenic, lead, and mercury. This safeguard is especially important for topical formulations, where repeated application over time could otherwise lead to gradual accumulation. Pharmaceutical-grade rapamycin keeps contaminants at trace levels defined by USP safety standards, protecting both safety and effectiveness.
We work with pharmacy partners who confirm through allergen and raw material declarations that this formulation is non-GMO. Avoiding genetically modified inputs helps maintain product integrity and minimizes potential sensitivities for long-term use.
Longevity Pathways
To affect longevity, we must understand its pathways
mTOR pathway
As skin ages, senescent cells accumulate with elevated mTOR activation, causing cellular hypergrowth and dysfunction. This leads to overexpression of IGF-2 in keratinocytes, resulting in skin overgrowth and wrinkles. Rapamycin inhibits mTOR activity, slowing senescence and cellular dysfunction in skin. Autophagy Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Autophagy
Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Senescence and Inflammation
Senescent cells trigger inflammation and aged appearance. Rapamycin reduces these aging cells and their inflammatory effects, promoting more graceful skin aging and sustained vitality.
Collagen Production
Collagen depletion causes wrinkles and sagging. Rapamycin influences the mTOR pathway to potentially boost collagen production, strengthening skin foundation for a more youthful appearance.
Skin Barrier and Resilience
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
Skin cell proliferation
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
mTOR pathway
As skin ages, senescent cells accumulate with elevated mTOR activation, causing cellular hypergrowth and dysfunction. This leads to overexpression of IGF-2 in keratinocytes, resulting in skin overgrowth and wrinkles. Rapamycin inhibits mTOR activity, slowing senescence and cellular dysfunction in skin. Autophagy Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Autophagy
Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Senescence and Inflammation
Senescent cells trigger inflammation and aged appearance. Rapamycin reduces these aging cells and their inflammatory effects, promoting more graceful skin aging and sustained vitality.
Collagen Production
Collagen depletion causes wrinkles and sagging. Rapamycin influences the mTOR pathway to potentially boost collagen production, strengthening skin foundation for a more youthful appearance.
Skin Barrier and Resilience
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
Skin cell proliferation
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
mTOR pathway
As skin ages, senescent cells accumulate with elevated mTOR activation, causing cellular hypergrowth and dysfunction. This leads to overexpression of IGF-2 in keratinocytes, resulting in skin overgrowth and wrinkles. Rapamycin inhibits mTOR activity, slowing senescence and cellular dysfunction in skin. Autophagy Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Autophagy
Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Senescence and Inflammation
Senescent cells trigger inflammation and aged appearance. Rapamycin reduces these aging cells and their inflammatory effects, promoting more graceful skin aging and sustained vitality.
Collagen Production
Collagen depletion causes wrinkles and sagging. Rapamycin influences the mTOR pathway to potentially boost collagen production, strengthening skin foundation for a more youthful appearance.
Skin Barrier and Resilience
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
Skin cell proliferation
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
mTOR pathway
As skin ages, senescent cells accumulate with elevated mTOR activation, causing cellular hypergrowth and dysfunction. This leads to overexpression of IGF-2 in keratinocytes, resulting in skin overgrowth and wrinkles. Rapamycin inhibits mTOR activity, slowing senescence and cellular dysfunction in skin. Autophagy Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Autophagy
Cellular waste buildup accelerates skin aging. Rapamycin promotes autophagy—the cellular cleanup process—reducing damage and maintaining healthier, more resilient skin over time.
Senescence and Inflammation
Senescent cells trigger inflammation and aged appearance. Rapamycin reduces these aging cells and their inflammatory effects, promoting more graceful skin aging and sustained vitality.
Collagen Production
Collagen depletion causes wrinkles and sagging. Rapamycin influences the mTOR pathway to potentially boost collagen production, strengthening skin foundation for a more youthful appearance.
Skin Barrier and Resilience
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
Skin cell proliferation
Rapamycin modulates mTOR signaling to enhance skin's natural defenses against environmental stressors like UV radiation and oxidative stress.
Included with Topical Rapamycin for Skin
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Hear from our patients
Topical rapamycin is the way to go!
Topical rapamycin is fantastic, better than anything I've used. I'm thrilled with the results. I tell friends to stop wasting money on pricey products that look nice but don't do anything to address cellular senescence in the skin caused by the sun
Angie Chevallier
The skin cream is great definitely want that again.
Rapamycin gives me more energy, it's amazing!!!The skin cream is great definitely want that again.
Carol B
My neck looks much better...
My hand pain is almost completely gone and I feel better than I did at 40. I think the topical is working too. My neck looks much better and there are fewer wrinkles.
Tammy White
Made a real difference.
Honestly, topical rapamycin is the first thing that’s actually made a real difference. My skin just looks smoother and healthier.
Patricia T
This is the area I experienced the most change
This is the area I experienced the most change. The banding in my neck and skin tags improved 95 %. I have little to no banding and skin tags are gone.
Michelle
Reviews
126 reviews
Frequently asked questions
Healthspan’s topical rapamycin isn’t a cosmetic quick fix—it’s a clinician-developed treatment that targets three critical drivers of skin aging: reducing the buildup of senescent cells, lowering inflammation in the skin layer, and boosting collagen production. Clinical research reflects these outcomes, showing topical rapamycin reduces key markers of skin cell senescence, improves fine lines, and increases collagen VII production—leading to smoother, firmer, and healthier skin over time.
Topical rapamycin works directly at the skin level, where aging is most visible. By targeting senescent cells and modulating mTOR locally, it reduces wrinkles, stimulates collagen, and supports autophagy without systemic exposure. Oral rapamycin is used to address whole-body aging, but topical delivery focuses on skin health specifically, offering a safer and more targeted option for improving firmness, texture, and tone.
Our topical rapamycin cream comes in 0.01%, 0.25%, and 1%. The right strength depends on your skin goals and tolerance. Our clinicians will guide you in choosing the best option for your needs.
A topical supplement is applied to the skin to deliver active compounds directly where they work. Healthspan’s topical rapamycin helps reduce senescent cells, improve repair, and smooth visible signs of aging.
Yes, Healthspan’s topical rapamycin is safe for use when applied as directed. Our product is carefully formulated in US-based pharmacies that strictly adhere to all applicable federal laws and FDA regulations. This ensures high-quality standards and safety for our customers.
The use of rapamycin, whether topical or oral, can cause fetal harm when administered to a pregnant woman. Therefore, topical rapamycin should not be used by women who are pregnant, planning to become pregnant, or breastfeeding.
Yes, obtaining topical rapamycin requires a prescription. Our physicians, all licensed in the United States, will conduct a thorough review of your health profile to assess your suitability for topical rapamycin. Upon approval, they will provide you with a personalized treatment plan, ensuring the treatment aligns with your specific health needs.
Apply in the evening to clean, dry skin. Start with 2–3 times per week to let your skin adjust, then increase as tolerated. Use a small, pea-sized amount and spread evenly across your face. Because topical rapamycin can make skin more sensitive to sunlight, apply SPF 30+ daily and avoid excessive sun exposure.
The most common negative side effect for first-time topical rapamycin users is dry skin. This is normally mild and lasts less than a week. For patients who experience discomfort, we recommend applying a chemical-free dermal hydration cream at night before bed.
Rapamycin can be used alongside retinoids, but we recommend alternating nights or starting with a low frequency to reduce irritation. Always use sunscreen, as both increase photosensitivity.
Yes. Avoid chemical peels, microdermabrasion, laser treatments, or other aggressive exfoliants on areas where topical rapamycin is applied. These procedures may increase skin sensitivity and the risk of irritation when combined with mTOR modulation. Always use a broad-spectrum SPF 30+ daily, and discontinue use temporarily if experiencing significant redness, peeling, or discomfort.
Healthspan’s topical rapamycin isn’t a cosmetic quick fix—it’s a clinician-developed treatment that targets three critical drivers of skin aging: reducing the buildup of senescent cells, lowering inflammation in the skin layer, and boosting collagen production. Clinical research reflects these outcomes, showing topical rapamycin reduces key markers of skin cell senescence, improves fine lines, and increases collagen VII production—leading to smoother, firmer, and healthier skin over time.
Topical rapamycin works directly at the skin level, where aging is most visible. By targeting senescent cells and modulating mTOR locally, it reduces wrinkles, stimulates collagen, and supports autophagy without systemic exposure. Oral rapamycin is used to address whole-body aging, but topical delivery focuses on skin health specifically, offering a safer and more targeted option for improving firmness, texture, and tone.
Our topical rapamycin cream comes in 0.01%, 0.25%, and 1%. The right strength depends on your skin goals and tolerance. Our clinicians will guide you in choosing the best option for your needs.
A topical supplement is applied to the skin to deliver active compounds directly where they work. Healthspan’s topical rapamycin helps reduce senescent cells, improve repair, and smooth visible signs of aging.
Yes, Healthspan’s topical rapamycin is safe for use when applied as directed. Our product is carefully formulated in US-based pharmacies that strictly adhere to all applicable federal laws and FDA regulations. This ensures high-quality standards and safety for our customers.
The use of rapamycin, whether topical or oral, can cause fetal harm when administered to a pregnant woman. Therefore, topical rapamycin should not be used by women who are pregnant, planning to become pregnant, or breastfeeding.
Yes, obtaining topical rapamycin requires a prescription. Our physicians, all licensed in the United States, will conduct a thorough review of your health profile to assess your suitability for topical rapamycin. Upon approval, they will provide you with a personalized treatment plan, ensuring the treatment aligns with your specific health needs.
Apply in the evening to clean, dry skin. Start with 2–3 times per week to let your skin adjust, then increase as tolerated. Use a small, pea-sized amount and spread evenly across your face. Because topical rapamycin can make skin more sensitive to sunlight, apply SPF 30+ daily and avoid excessive sun exposure.
The most common negative side effect for first-time topical rapamycin users is dry skin. This is normally mild and lasts less than a week. For patients who experience discomfort, we recommend applying a chemical-free dermal hydration cream at night before bed.
Rapamycin can be used alongside retinoids, but we recommend alternating nights or starting with a low frequency to reduce irritation. Always use sunscreen, as both increase photosensitivity.
Yes. Avoid chemical peels, microdermabrasion, laser treatments, or other aggressive exfoliants on areas where topical rapamycin is applied. These procedures may increase skin sensitivity and the risk of irritation when combined with mTOR modulation. Always use a broad-spectrum SPF 30+ daily, and discontinue use temporarily if experiencing significant redness, peeling, or discomfort.