Low Dose Naltrexone (LDN)
A prescription therapy that calms overactive immune responses and enhances the body’s natural pain- and mood-regulating pathways to support improved energy and long-term health.
Targets inflammation at the root of aging, quieting overactive immune signals while boosting endorphins, to improve how you feel.
Gently stimulates endorphin production, lifting mood, reducing fatigue, restoring resilience, and promoting healthspan across multiple systems.
Supports cognitive resilience and emotional balance by reducing overactive immune cells in the brain.
Reclaim your natural vitality
Reducing chronic inflammation
LDN helps calm immune overactivity by blocking TLR4 signaling and rebalancing cytokine activity. Lowering inflammatory signals protects tissues and eases the cycle behind many chronic conditions.
Easing pain and sensitivity
LDN briefly blocks opioid receptors, prompting a rise in natural, pain-killing endorphins and enkephalins. Calming pain pathways can reduce sensitivity and improve daily comfort in conditions like fibromyalgia.
Enhancing gut health
LDN reduces gut inflammation and endoplasmic reticulum stress in intestinal cells. Restoring immune balance in the gut lining helps improve symptoms, promote tissue healing, and maintain remission.
Quieting nerve hyperactivity
In the brain and spinal cord, microglia can become hyperactive, flooding tissues with signals that worsen pain and fatigue. LDN reduces microglial activation, lowering inflammation and easing hypersensitivity.
Enhancing sleep quality
LDN rebalances opioid signaling and lowers inflammatory mediators that disrupt circadian rhythms to restore deeper, more restorative sleep.
Promoting metabolic balance
LDN improves insulin sensitivity and glucose tolerance while lowering inflammation linked to hyperinsulinemia, supporting better metabolic health and reducing risk factors for age-related disease.
Boosting mood and well-being
The increase in endorphins triggered by LDN does more than reduce pain, it also improves mood, lowers stress, and enhances overall feelings of well-being.
Rigorously tested for purity and potency
Purity is measured to confirm that nearly all of the material is the active compound. At around 99.5% purity, pharmaceutical-grade naltrexone avoids contaminants or degraded byproducts that could interfere with its effectiveness or increase the risk of unwanted side effects. This is especially important for LDN, as it is compounded at much smaller doses than standard naltrexone.
Potency is verified every 3–6 months to confirm each batch remains within ±10% of the intended concentration. With LDN, this precision is critical: since doses are typically one-tenth or less of standard formulations, even minor deviations can impact immune modulation and therapeutic benefit. Consistent potency ensures reliable results at these carefully calibrated low doses.
Trace metal testing ensures ingredients remain free from unsafe levels of arsenic, lead, and mercury. This safeguard is vital for compounded therapies like LDN, where long-term daily use means that even small amounts of contaminants could accumulate over time. Pharmaceutical-grade naltrexone adheres to USP safety standards, keeping heavy metals at trace levels and preserving both safety and effectiveness.
We work with pharmacy partners who confirm through allergen and raw material declarations that this formulation is non-GMO. Avoiding genetically modified inputs helps maintain product consistency and minimizes potential sensitivities, supporting long-term safety for chronic use.
Longevity Pathways
To affect longevity, we must understand its pathways
Inflammation Reduction
LDN fine-tunes immune responses to counteract chronic "inflammaging," offering a pathway to healthier aging by reducing inflammation's negative effects on the body.
Endorphin Systems
LDN increases natural endorphin production, potentially affecting aging pathways tied to mood, pain perception, and overall well-being through the body's natural painkiller system.
Oxidative Stress
LDN reduces oxidative stress by enhancing the body's antioxidant defenses against harmful free radicals, slowing cellular wear and tear for more resilient aging.
Autoimmunity
LDN modulates chronic inflammatory responses by regulating cytokine release from immune cells, bringing inflammation closer to optimal levels and reducing tissue dysfunction.
Inflammation Reduction
LDN fine-tunes immune responses to counteract chronic "inflammaging," offering a pathway to healthier aging by reducing inflammation's negative effects on the body.
Endorphin Systems
LDN increases natural endorphin production, potentially affecting aging pathways tied to mood, pain perception, and overall well-being through the body's natural painkiller system.
Oxidative Stress
LDN reduces oxidative stress by enhancing the body's antioxidant defenses against harmful free radicals, slowing cellular wear and tear for more resilient aging.
Autoimmunity
LDN modulates chronic inflammatory responses by regulating cytokine release from immune cells, bringing inflammation closer to optimal levels and reducing tissue dysfunction.
Inflammation Reduction
LDN fine-tunes immune responses to counteract chronic "inflammaging," offering a pathway to healthier aging by reducing inflammation's negative effects on the body.
Endorphin Systems
LDN increases natural endorphin production, potentially affecting aging pathways tied to mood, pain perception, and overall well-being through the body's natural painkiller system.
Oxidative Stress
LDN reduces oxidative stress by enhancing the body's antioxidant defenses against harmful free radicals, slowing cellular wear and tear for more resilient aging.
Autoimmunity
LDN modulates chronic inflammatory responses by regulating cytokine release from immune cells, bringing inflammation closer to optimal levels and reducing tissue dysfunction.
Inflammation Reduction
LDN fine-tunes immune responses to counteract chronic "inflammaging," offering a pathway to healthier aging by reducing inflammation's negative effects on the body.
Endorphin Systems
LDN increases natural endorphin production, potentially affecting aging pathways tied to mood, pain perception, and overall well-being through the body's natural painkiller system.
Oxidative Stress
LDN reduces oxidative stress by enhancing the body's antioxidant defenses against harmful free radicals, slowing cellular wear and tear for more resilient aging.
Autoimmunity
LDN modulates chronic inflammatory responses by regulating cytokine release from immune cells, bringing inflammation closer to optimal levels and reducing tissue dysfunction.
Included with Low dose Naltrexone
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Hear from our patients
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Frequently asked questions
LDN is a low-dose formulation of naltrexone used to enhance immune function, combat fatigue, and reduce chronic inflammation in autoimmune and pain-related conditions.
LDN temporarily blocks opioid receptors, prompting the body to increase its production of endorphins. It also inhibits TLR4 and reduces microglial inflammation—lowering chronic inflammation and oxidative stress.
LDN is used off-label to support fibromyalgia, long COVID, MS, Crohn’s disease, rheumatoid arthritis, and chronic fatigue-related conditions. Study →
Naltrexone is FDA-approved at higher doses for substance use disorders. LDN is prescribed off-label for reducing chronic inflammation, immune support, and chronic pain.
Some users report better sleep or mood within 1–2 weeks. Most experience significant results in energy, inflammation, and cognitive function by 6–8 weeks.
Yes. Many clients use LDN alongside Rapamycin, Methylene Blue, or Oxytocin for multi-pathway support.
LDN is generally well-tolerated. Mild side effects like vivid dreams, nausea, or temporary sleep disturbances may occur and usually resolve quickly.
Avoid concurrent use with opioids. Always consult your Healthspan clinician to check for drug interactions.
Starting doses range from 1mg–1.5mg, titrated to 4.5mg daily based on tolerance and response.
Most users benefit from 6–12 months of consistent use. Long-term use may help maintain results for chronic inflammation and fatigue.
LDN is a low-dose formulation of naltrexone used to enhance immune function, combat fatigue, and reduce chronic inflammation in autoimmune and pain-related conditions.
LDN temporarily blocks opioid receptors, prompting the body to increase its production of endorphins. It also inhibits TLR4 and reduces microglial inflammation—lowering chronic inflammation and oxidative stress.
LDN is used off-label to support fibromyalgia, long COVID, MS, Crohn’s disease, rheumatoid arthritis, and chronic fatigue-related conditions. Study →
Naltrexone is FDA-approved at higher doses for substance use disorders. LDN is prescribed off-label for reducing chronic inflammation, immune support, and chronic pain.
Some users report better sleep or mood within 1–2 weeks. Most experience significant results in energy, inflammation, and cognitive function by 6–8 weeks.
Yes. Many clients use LDN alongside Rapamycin, Methylene Blue, or Oxytocin for multi-pathway support.
LDN is generally well-tolerated. Mild side effects like vivid dreams, nausea, or temporary sleep disturbances may occur and usually resolve quickly.
Avoid concurrent use with opioids. Always consult your Healthspan clinician to check for drug interactions.
Starting doses range from 1mg–1.5mg, titrated to 4.5mg daily based on tolerance and response.
Most users benefit from 6–12 months of consistent use. Long-term use may help maintain results for chronic inflammation and fatigue.
