Rapamycin
One of the most comprehensive longevity interventions available, Rapamycin addresses several molecular processes at once to slow the aging process and promote cellular health.
Resets hyperactive mTOR signaling that accelerates aging back to youthful levels, slowing down biological aging at a cellular level.
Clears senescent cells and reduces their harmful inflammatory signals to restore healthier tissue function.
Stimulate your body's natural and essential cleaning process to clear cellular damage and maintain cellular health critical for longevity.
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Ahead of the field
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
“I would say that rapamycin is the current best-in-class for a longevity drug”
“Rapamycin... is at the leading edge of a generation of research trials.”
Our patients see an average reduction in biological age of
8 years
Go beneath the surface of aging
Activating autophagy
Rapamycin inhibits the mTOR pathway to trigger autophagy, a natural process for removing damaged cellular material. Aiding autophagy enhances tissue regeneration and supports healthy aging.
Reducing senescence
Rapamycin inhibits mTOR to slow the accumulation of senescent cells that release inflammatory signals and damage surrounding tissues, helping preserve tissue function and reduce age-related decline.
Enhancing mitochondria
Rapamycin activates mitophagy to clear damaged mitochondria while promoting the generation of new, healthy ones, improving cellular energy production and supporting optimal function across vital organs.
Protecting brain function
Rapamycin targets neuroinflammation, protein misfolding, and mitochondrial dysfunction to preserve cognitive performance and reduce risk of age-related neurodegeneration, when started early.
Reducing inflammation
Rapamycin reduces chronic, low-grade inflammation that accelerates aging and tissue damage, helping preserve organ function and extend the years of healthy, active living.
Reducing cancer risk
Rapamycin may help reduce tumorigenic potential by acting as a molecular brake on cellular overgrowth and reducing inflammatory signals associated with increased cancer risk, though outcomes may vary.
Dosing is everything
The highest quality, made for you
Rapamycin only works if it’s absorbed. That’s why our protocol relies on FDA-approved, enteric-coated tablets designed to withstand stomach acid and release rapamycin in the intestine for reliable bioavailability. This avoids the instability and poor absorption often seen with compounded capsules or raw powder.
Consistency matters at every dose. Each prescription is personalized by a U.S.-licensed physician, with the option of a Sirolimus blood panel to directly measure absorption and confirm therapeutic levels. This ensures your protocol is safe, effective, and tailored to your biology.
Our rapamycin is sourced only from FDA-approved manufacturers and dispensed through NABP-accredited U.S. pharmacies. Every batch is tested under USP standards for identity, strength, and purity—eliminating the risks associated with unregulated or international sources.
While our protocol is built on FDA-approved generics for their proven absorption, we understand some patients may prefer compounded rapamycin. In these cases, we provide access to trusted compounding pharmacies with complimentary bioavailability testing. This ensures absorption is confirmed and dosing can be adjusted to the same high standard of safety and effectiveness.
Going Deeper
Cellular pathways are roads to peak performance
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Inflammation
Reduces senescent cell buildup and inflammation by rebalancing the AMPK and mTOR signaling axis.
Cellular Renewal
Promotes mitophagy to remove damaged mitochondria, enhancing energy production and metabolic efficiency.
Metabolic Flexibility
Regulates insulin signaling, reduces glucose variability, and supports fat oxidation to stabilize energy and optimize metabolic health.
Autophagy Activation
Boosts autophagy to clear cellular waste, aid repair, and sustain long-term tissue function.
AMPK-mTOR Regulation
Coordinates repair and growth signals by optimizing the AMPK and mTOR pathways—key drivers of cellular aging and resilience.
Included with your Rapamycin Protocol
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Hear from our patients
Nothing short of miraculous...
Osteoarthritis pains improved 97%, pain in my neck is gone! All this and Ive just entered week 4 of treatment with Rapamycin. Can hardly wait for week 8 to see how much more Ill be amazed!!
Paul Windhausen
My joint pain has got so much better.
I really appreciate how they review blood work with me and guide me through the process. My joint pain has got so much better. I am glad that they have figured a way to make Rapamycin more available
Stephanie
Labs, progress, and care. All dialed in.
Healthspan provides great care when prescribing Rapamycin alongside frequent lab tests and detailed progress monitoring
Jspflorida
Reviews
124 reviews
Frequently asked questions
Your protocol includes a fully personalized dosing plan based on lab data, free biomarker testing, access to high-bioavailability rapamycin, and direct guidance from our clinical support team. You’ll also get access to a personalized dashboard to monitor results and track changes in biological age, mTOR activity, and more.
Yes. We only source from certified pharmacies and validate the bioavailability of every batch. Rapamycin absorption varies—so we use pharmacokinetic testing standards like Tmax and Cmax to select the most reliable formulations.
Your panel includes key metabolic, inflammatory, and longevity biomarkers—ApoB, hs-CRP, IGF-1, insulin sensitivity, liver function, and more. These help us assess autophagy activation, mTOR activity, and aging trends.
We prioritize generic rapamycin for its proven absorption profile (3x higher than compounded). Compounded formulations are available in special cases but are not our first-line approach.
When dosed intermittently and monitored by our team, rapamycin can be used safely for long-term healthspan support. Weekly protocols are designed to avoid mTORC2 inhibition and minimize immune suppression.
You’ll typically start with 3mg weekly and titrate up based on labs. Most patients stabilize between 5–8mg/week. All doses are taken once per week—not daily—to optimize autophagy and avoid continuous mTOR inhibition.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
Yes—rapamycin was originally developed as an immunosuppressant for organ transplant recipients. In that setting, it’s used at high, continuous doses that inhibit both mTORC1 and mTORC2, leading to broad immune suppression. In contrast, longevity protocols use low, intermittent doses designed to selectively inhibit mTORC1 only, while sparing mTORC2. This preserves immune function and instead promotes beneficial effects like autophagy activation, cellular repair, and inflammation reduction.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.
Your protocol includes a fully personalized dosing plan based on lab data, free biomarker testing, access to high-bioavailability rapamycin, and direct guidance from our clinical support team. You’ll also get access to a personalized dashboard to monitor results and track changes in biological age, mTOR activity, and more.
Yes. We only source from certified pharmacies and validate the bioavailability of every batch. Rapamycin absorption varies—so we use pharmacokinetic testing standards like Tmax and Cmax to select the most reliable formulations.
Your panel includes key metabolic, inflammatory, and longevity biomarkers—ApoB, hs-CRP, IGF-1, insulin sensitivity, liver function, and more. These help us assess autophagy activation, mTOR activity, and aging trends.
We prioritize generic rapamycin for its proven absorption profile (3x higher than compounded). Compounded formulations are available in special cases but are not our first-line approach.
When dosed intermittently and monitored by our team, rapamycin can be used safely for long-term healthspan support. Weekly protocols are designed to avoid mTORC2 inhibition and minimize immune suppression.
You’ll typically start with 3mg weekly and titrate up based on labs. Most patients stabilize between 5–8mg/week. All doses are taken once per week—not daily—to optimize autophagy and avoid continuous mTOR inhibition.
We strongly recommend labs for dose optimization and to track effects on mTOR, autophagy, and inflammation. Your labs are included at no additional cost.
You do not need a separate physician. Our clinical support team handles onboarding, optimization, and regular lab reviews to guide your journey.
Yes—rapamycin was originally developed as an immunosuppressant for organ transplant recipients. In that setting, it’s used at high, continuous doses that inhibit both mTORC1 and mTORC2, leading to broad immune suppression. In contrast, longevity protocols use low, intermittent doses designed to selectively inhibit mTORC1 only, while sparing mTORC2. This preserves immune function and instead promotes beneficial effects like autophagy activation, cellular repair, and inflammation reduction.
Rapamycin may not be suitable for individuals with uncontrolled infections, severely impaired immune systems, recent major surgeries, or those who are pregnant or breastfeeding. All protocols are reviewed by a physician to ensure safety based on your health profile.