Oxytocin Nasal Spray
A science-backed prescribed oxytocin protocol to reduce stress, lower cortisol, and improve mood, heart health, and long-term resilience.
Regulates stress hormone pathways to reduce cortisol-driven inflammation while supporting healthy stress adaptation and recovery.
Reduces cortisol and stress reactivity and promotes parasympathetic activation to support mood stability and restorative sleep quality.
Targets multiple aging pathways including inflammation reduction, stress recovery, and cellular repair systems linked to healthy aging.
The scientific way to stress relief
Reducing brain inflammation
Suppresses harmful inflammatory cytokines and regulates microglial activation while modulating immune signaling pathways, supporting healthy brain aging by controlling neuroinflammation.
Enhancing autonomic balance
Improves heart rate variability and parasympathetic activation while supporting CV health and blood pressure regulation, optimizing the nervous system's stress response and recovery mechanisms.
Supporting mitochondrial health
Boosts antioxidant enzyme activity and reduces oxidative damage to neuronal membranes and mitochondria, helping maintain cellular energy production and protecting against neuronal decline.
Optimizing neural signaling
Regulates brain receptors and enhances calming pathways to improve learning ability while preventing damage from overactive brain cells, maintaining required balance for optimal mental function.
Neurogenesis and brain plasticity
Early research indicates oxytocin stimulates growth of new neurons and aids their integration into existing networks, enhancing memory and learning while counteracting age-related brain cell decline.
Strengthening gut barrier function
Improves intestinal muscle activity and strengthens tight junctions to reduce "leaky gut" while maintaining optimal nutrient absorption structures, aiding digestive health and reducing inflammation.
Controlling gut inflammation
Dampens inflammatory cytokines including IL-6 and TNF-α through vagus nerve signaling while modulating immune cell activity, helping prevent chronic gut inflammation and conditions like IBD and IBS.
Optimizing microbiome diversity
Promotes “good” bacteria such as Lactobacillus and Bifidobacterium while preventing harmful bacterial overgrowth, supporting microbial diversity and defending against dysbiosis that drives inflammation and metabolic dysfunction.
Supporting gut-brain connection
Supports beneficial gut bacteria that stimulate natural oxytocin production in the brain, creating a positive feedback loop that reinforces stress resilience, emotional health, and digestive function.
Enhancing metabolic function
Regulates appetite hormones and improves insulin sensitivity while promoting gut bacteria that produce helpful fatty acids, supporting weight management, glucose metabolism, and longevity pathways.
Preserving muscle mass
Activates stem cells and stimulates regenerative pathways to aid in muscle repair and prevent age-related muscle loss, helping maintain strength and function while slowing sarcopenia progression.
Enhancing fat metabolism
Regulates energy balance and suppresses excessive food intake while improving lean-to-fat ratios, helping reduce visceral fat accumulation and prevent obesity even without calorie restriction.
Improving cardiovascular health
Clinical trials show oxytocin reduces LDL cholesterol levels while improving body composition (more lean mass, reduced fat mass,) addressing key risk factors for metabolic syndrome and CV disease.
Supporting heart and vessel health
Promotes blood vessel dilation through nitric oxide while reducing blood pressure via brain and kidney pathways, supporting cardiac repair and preventing harmful heart muscle changes due to aging.
The highest standards of care
Purity is measured to confirm that nearly all of the material is the active compound. At around 99.5% purity, pharmaceutical-grade oxytocin avoids contaminants such as peptide fragments or excipients that could interfere with stability, absorption, or increase the risk of side effects.
Potency is verified every 3–6 months to confirm each batch remains within ±10% of the intended concentration. For oxytocin, this precision is especially important—too little may limit its effectiveness in mood or stress support, while too much can increase the risk of side effects. Consistent potency ensures reliable therapeutic benefits with each dose.
Trace metal testing ensures ingredients remain free from unsafe levels of arsenic, lead, and mercury. For oxytocin, this safeguard is critical. Lower-grade sources of peptide ingredients may contain impurities or trace metals that accumulate over time. Even small amounts, when taken repeatedly, can increase the risk of inflammation, oxidative stress, or long-term toxicity. Pharmaceutical-grade oxytocin keeps contaminants at trace levels defined by USP safety standards, protecting both effectiveness and long-term health.
We work with pharmacy partners who confirm through allergen and raw material declarations that this formulation is non-GMO. Avoiding genetically modified inputs helps maintain product reliability and minimizes potential sensitivities for long-term use.
Going Deeper
Cellular pathways are roads to peak performance
The mTOR Pathway
Oxytocin modulates the mTOR pathway to promote autophagy and reduce cellular senescence. This enhances cellular cleanup and maintains vitality, preventing age-related diseases and promoting longevity.
Cellular Senescence
Oxytocin reduces senescence markers and clears senescent cells while decreasing pro-inflammatory factors. This maintains cellular regenerative capacity and supports healthy aging.
Enhanced Stem Cell Function
Oxytocin rejuvenates aged muscle stem cells and activates the MAPK/ERK pathway. This supports stem cell proliferation, survival, and tissue repair, maintaining muscle function and combating age-related decline.
The AMPK Pathway
Oxytocin activates AMPK to enhance metabolic efficiency and energy homeostasis. This improves glucose uptake, fatty acid oxidation, and promotes autophagy for cellular cleanup and metabolic health.
Reduces Chronic Inflammation
Oxytocin modulates the NF-κB pathway to reduce pro-inflammatory cytokines and lower systemic inflammation. This helps prevent inflammation-related aging diseases and supports healthier aging.
HPA Axis Modulation
Oxytocin regulates the stress response by reducing HPA axis activity and cortisol levels. This decreases stress and anxiety while improving immune function and metabolic health.
The mTOR Pathway
Oxytocin modulates the mTOR pathway to promote autophagy and reduce cellular senescence. This enhances cellular cleanup and maintains vitality, preventing age-related diseases and promoting longevity.
Cellular Senescence
Oxytocin reduces senescence markers and clears senescent cells while decreasing pro-inflammatory factors. This maintains cellular regenerative capacity and supports healthy aging.
Enhanced Stem Cell Function
Oxytocin rejuvenates aged muscle stem cells and activates the MAPK/ERK pathway. This supports stem cell proliferation, survival, and tissue repair, maintaining muscle function and combating age-related decline.
The AMPK Pathway
Oxytocin activates AMPK to enhance metabolic efficiency and energy homeostasis. This improves glucose uptake, fatty acid oxidation, and promotes autophagy for cellular cleanup and metabolic health.
Reduces Chronic Inflammation
Oxytocin modulates the NF-κB pathway to reduce pro-inflammatory cytokines and lower systemic inflammation. This helps prevent inflammation-related aging diseases and supports healthier aging.
HPA Axis Modulation
Oxytocin regulates the stress response by reducing HPA axis activity and cortisol levels. This decreases stress and anxiety while improving immune function and metabolic health.
The mTOR Pathway
Oxytocin modulates the mTOR pathway to promote autophagy and reduce cellular senescence. This enhances cellular cleanup and maintains vitality, preventing age-related diseases and promoting longevity.
Cellular Senescence
Oxytocin reduces senescence markers and clears senescent cells while decreasing pro-inflammatory factors. This maintains cellular regenerative capacity and supports healthy aging.
Enhanced Stem Cell Function
Oxytocin rejuvenates aged muscle stem cells and activates the MAPK/ERK pathway. This supports stem cell proliferation, survival, and tissue repair, maintaining muscle function and combating age-related decline.
The AMPK Pathway
Oxytocin activates AMPK to enhance metabolic efficiency and energy homeostasis. This improves glucose uptake, fatty acid oxidation, and promotes autophagy for cellular cleanup and metabolic health.
Reduces Chronic Inflammation
Oxytocin modulates the NF-κB pathway to reduce pro-inflammatory cytokines and lower systemic inflammation. This helps prevent inflammation-related aging diseases and supports healthier aging.
HPA Axis Modulation
Oxytocin regulates the stress response by reducing HPA axis activity and cortisol levels. This decreases stress and anxiety while improving immune function and metabolic health.
The mTOR Pathway
Oxytocin modulates the mTOR pathway to promote autophagy and reduce cellular senescence. This enhances cellular cleanup and maintains vitality, preventing age-related diseases and promoting longevity.
Cellular Senescence
Oxytocin reduces senescence markers and clears senescent cells while decreasing pro-inflammatory factors. This maintains cellular regenerative capacity and supports healthy aging.
Enhanced Stem Cell Function
Oxytocin rejuvenates aged muscle stem cells and activates the MAPK/ERK pathway. This supports stem cell proliferation, survival, and tissue repair, maintaining muscle function and combating age-related decline.
The AMPK Pathway
Oxytocin activates AMPK to enhance metabolic efficiency and energy homeostasis. This improves glucose uptake, fatty acid oxidation, and promotes autophagy for cellular cleanup and metabolic health.
Reduces Chronic Inflammation
Oxytocin modulates the NF-κB pathway to reduce pro-inflammatory cytokines and lower systemic inflammation. This helps prevent inflammation-related aging diseases and supports healthier aging.
HPA Axis Modulation
Oxytocin regulates the stress response by reducing HPA axis activity and cortisol levels. This decreases stress and anxiety while improving immune function and metabolic health.
Included with Oxytocin
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Hear from our patients
Hope they offer more products in the future!
I was initially interested in Oxytocin, but ended up going all out with the company. Everything has been incredibly smooth, the response time and assistance is fantastic, and complaints are handled with upmost professionalism.
Cody Clem
Just wow
I’m ramping up my intranasal oxytocin protocol and I can’t believe the improvement it’s already making. I suffer from various conditions, and it’s making an impact on most of them. My pain, stress, and anxiety have taken a nosedive.
Ned Drummond
This stuff works!
I have been using the Oxytocin nasal spray for the last 3 months and definitely notice a difference in my mood, my joint aches/pains and I find I feel more relaxed day to day.
Dori T
Reviews
126 reviews
Frequently asked questions
A naturally occurring hormone and neuropeptide involved in bonding, cortisol regulation, and cellular repair.
Oxytocin is delivered via nasal spray, typically 2 sprays daily as prescribed.
Most users feel reduced stress and mood lift within 1–3 weeks. Full benefits build over 1–3 months.
Yes. Our formulations are compounded by licensed pharmacies with clinician oversight.
Yes. It is safe alongside Rapamycin, Metformin, SGLT2, and more.
No. Avoid use while pregnant or nursing.
Yes, for certain indications. Longevity and stress-related use is off-label under clinical supervision.
Stress recovery, cortisol balance, emotional stability, cardiovascular support, and brain health.
Keep refrigerated at 35.6°F–46.4°F (2°C–8°C). Do not freeze.
Yes. It can stay unrefrigerated up to 104°F for 2 weeks. For longer travel, use an insulated bag.
No. Oxytocin is not addictive and does not create dependency. It works by enhancing natural hormone signaling and does not stimulate dopamine in the same way as addictive substances.
Oxytocin sold on marketplaces is often unregulated and may not contain pharmaceutical-grade ingredients. Our formulation is prescription-only, clinically guided, and compounded in U.S.-certified pharmacies to ensure purity, consistency, and efficacy.
Our oxytocin nasal spray is compounded at 15 IU per spray. Dosing (the number of daily sprays) varies depending on clinical goals and tolerance. Your protocol is customized and titrated under clinician guidance.
A naturally occurring hormone and neuropeptide involved in bonding, cortisol regulation, and cellular repair.
Oxytocin is delivered via nasal spray, typically 2 sprays daily as prescribed.
Most users feel reduced stress and mood lift within 1–3 weeks. Full benefits build over 1–3 months.
Yes. Our formulations are compounded by licensed pharmacies with clinician oversight.
Yes. It is safe alongside Rapamycin, Metformin, SGLT2, and more.
No. Avoid use while pregnant or nursing.
Yes, for certain indications. Longevity and stress-related use is off-label under clinical supervision.
Stress recovery, cortisol balance, emotional stability, cardiovascular support, and brain health.
Keep refrigerated at 35.6°F–46.4°F (2°C–8°C). Do not freeze.
Yes. It can stay unrefrigerated up to 104°F for 2 weeks. For longer travel, use an insulated bag.
No. Oxytocin is not addictive and does not create dependency. It works by enhancing natural hormone signaling and does not stimulate dopamine in the same way as addictive substances.
Oxytocin sold on marketplaces is often unregulated and may not contain pharmaceutical-grade ingredients. Our formulation is prescription-only, clinically guided, and compounded in U.S.-certified pharmacies to ensure purity, consistency, and efficacy.
Our oxytocin nasal spray is compounded at 15 IU per spray. Dosing (the number of daily sprays) varies depending on clinical goals and tolerance. Your protocol is customized and titrated under clinician guidance.