Methylene Blue
A cutting-edge longevity protocol shown in clinical research to enhance mitochondrial function, improve mental clarity, and support long-term brain resilience.
Enhances focus and emotional balance by restoring neuronal energy.
Targets mitochondrial dysfunction to improve how your cells produce and sustain energy.
Reinforces mitochondrial health to slow neurodegeneration.
Activate your body's natural resilience
Enhancing mitochondrial function
Promotes mitochondrial health, boosts ATP generation, and supports sustained cellular energy critical for brain performance, metabolic health, and aging resilience.
Boosting cognitive function
Improves mental clarity, memory, and focus by enhancing neuronal mitochondrial activity and optimizing neurotransmitter signaling.
Reducing oxidative stress
Acts as a potent antioxidant to neutralize reactive oxygen species (ROS), protecting neurons from inflammation and age-related decline.
Enhancing cerebral blood flow
Optimizes nitric oxide signaling to improve brain circulation and oxygen delivery, supporting cognitive performance and mental clarity.
Optimizing vascular and oxygen delivery
Boosts oxygen utilization efficiency and stimulates nitric oxide release for improved vasodilation, aiding cerebral blood flow and glucose uptake to combat brain hypometabolism and support neural function.
Reducing neuronal oxidative stress
Functions as a recyclable antioxidant that captures stray electrons before they form harmful reactive oxygen species, preventing cellular damage while supporting clean mitochondrial energy production.
Not all Methylene Blue measures up
Providers focused on specific aspects of care can miss the big picture or skip steps. Healthspan connects the dots and never cuts corners.
Going Deeper
Cellular pathways are roads to peak performance
Mitochondrial Energy Production
Methylene blue acts as a backup route when mitochondrial energy production is damaged, maintaining stable ATP levels while reducing harmful free radical formation.
Antioxidant Pathways
Methylene blue neutralizes free radicals by switching between oxidized and reduced forms, while supporting the body's natural antioxidant defenses against oxidative damage.
Nitric Oxide (NO) Pathway
Methylene blue balances nitric oxide levels by preventing excessive production, protecting the brain, cardiovascular system, and other tissues from NO-related damage.
Autophagy and Mitophagy
Methylene blue promotes cellular cleanup processes that remove general waste (autophagy) and damaged mitochondria (mitophagy), maintaining a healthier cellular environment for longevity.
Neuroprotection and Plasticity
Methylene blue boosts BDNF production for neuron growth and influences neurotransmitters like serotonin and dopamine, enhancing mood and cognitive performance for long-term brain health.
Protein Aggregation
Methylene blue prevents misfolded proteins from forming toxic clumps that damage neurons and contribute to disorders like Alzheimer's, potentially slowing neurodegenerative processes.
Inflammatory Pathways
Methylene blue modulates NF-κB to reduce pro-inflammatory molecules, keeping chronic inflammation in check to support overall health and delay age-related disorders.
Gene Expression
Methylene blue activates pathways for mitochondrial biogenesis and oxidative stress defense, influencing gene expression to promote cellular repair and maintenance for healthy aging.
Mitochondrial Energy Production
Methylene blue acts as a backup route when mitochondrial energy production is damaged, maintaining stable ATP levels while reducing harmful free radical formation.
Antioxidant Pathways
Methylene blue neutralizes free radicals by switching between oxidized and reduced forms, while supporting the body's natural antioxidant defenses against oxidative damage.
Nitric Oxide (NO) Pathway
Methylene blue balances nitric oxide levels by preventing excessive production, protecting the brain, cardiovascular system, and other tissues from NO-related damage.
Autophagy and Mitophagy
Methylene blue promotes cellular cleanup processes that remove general waste (autophagy) and damaged mitochondria (mitophagy), maintaining a healthier cellular environment for longevity.
Neuroprotection and Plasticity
Methylene blue boosts BDNF production for neuron growth and influences neurotransmitters like serotonin and dopamine, enhancing mood and cognitive performance for long-term brain health.
Protein Aggregation
Methylene blue prevents misfolded proteins from forming toxic clumps that damage neurons and contribute to disorders like Alzheimer's, potentially slowing neurodegenerative processes.
Inflammatory Pathways
Methylene blue modulates NF-κB to reduce pro-inflammatory molecules, keeping chronic inflammation in check to support overall health and delay age-related disorders.
Gene Expression
Methylene blue activates pathways for mitochondrial biogenesis and oxidative stress defense, influencing gene expression to promote cellular repair and maintenance for healthy aging.
Mitochondrial Energy Production
Methylene blue acts as a backup route when mitochondrial energy production is damaged, maintaining stable ATP levels while reducing harmful free radical formation.
Antioxidant Pathways
Methylene blue neutralizes free radicals by switching between oxidized and reduced forms, while supporting the body's natural antioxidant defenses against oxidative damage.
Nitric Oxide (NO) Pathway
Methylene blue balances nitric oxide levels by preventing excessive production, protecting the brain, cardiovascular system, and other tissues from NO-related damage.
Autophagy and Mitophagy
Methylene blue promotes cellular cleanup processes that remove general waste (autophagy) and damaged mitochondria (mitophagy), maintaining a healthier cellular environment for longevity.
Neuroprotection and Plasticity
Methylene blue boosts BDNF production for neuron growth and influences neurotransmitters like serotonin and dopamine, enhancing mood and cognitive performance for long-term brain health.
Protein Aggregation
Methylene blue prevents misfolded proteins from forming toxic clumps that damage neurons and contribute to disorders like Alzheimer's, potentially slowing neurodegenerative processes.
Inflammatory Pathways
Methylene blue modulates NF-κB to reduce pro-inflammatory molecules, keeping chronic inflammation in check to support overall health and delay age-related disorders.
Gene Expression
Methylene blue activates pathways for mitochondrial biogenesis and oxidative stress defense, influencing gene expression to promote cellular repair and maintenance for healthy aging.
Mitochondrial Energy Production
Methylene blue acts as a backup route when mitochondrial energy production is damaged, maintaining stable ATP levels while reducing harmful free radical formation.
Antioxidant Pathways
Methylene blue neutralizes free radicals by switching between oxidized and reduced forms, while supporting the body's natural antioxidant defenses against oxidative damage.
Nitric Oxide (NO) Pathway
Methylene blue balances nitric oxide levels by preventing excessive production, protecting the brain, cardiovascular system, and other tissues from NO-related damage.
Autophagy and Mitophagy
Methylene blue promotes cellular cleanup processes that remove general waste (autophagy) and damaged mitochondria (mitophagy), maintaining a healthier cellular environment for longevity.
Neuroprotection and Plasticity
Methylene blue boosts BDNF production for neuron growth and influences neurotransmitters like serotonin and dopamine, enhancing mood and cognitive performance for long-term brain health.
Protein Aggregation
Methylene blue prevents misfolded proteins from forming toxic clumps that damage neurons and contribute to disorders like Alzheimer's, potentially slowing neurodegenerative processes.
Inflammatory Pathways
Methylene blue modulates NF-κB to reduce pro-inflammatory molecules, keeping chronic inflammation in check to support overall health and delay age-related disorders.
Gene Expression
Methylene blue activates pathways for mitochondrial biogenesis and oxidative stress defense, influencing gene expression to promote cellular repair and maintenance for healthy aging.
Included with Methylene Blue
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Healthspan personalized treatment protocols include professional clinical support on an ongoing basis. With MySpan, you can track your progress in real time—upload photos, record changes, and monitor how your protocol responds to treatment, all in one place.
Dosing is everything
Rigorously tested for purity and potency
Purity is measured to confirm that nearly all of the material is the active compound. At around 99.5% purity, pharmaceutical-grade methylene blue avoids contaminants that can interfere with its effectiveness or increase the risk of side effects.
Potency is verified every 3–6 months to confirm each batch remains within ±10% of the intended concentration. For methylene blue, this precision is especially important—too little may limit effectiveness, while too much can increase the risk of side effects.
Trace metal testing ensures ingredients remain free from unsafe levels of arsenic, lead, and mercury. For methylene blue, this safeguard is critical. Lower-grade or industrial sources can contain 8–10% impurities, including heavy metals that may accumulate in the body over time. Even small amounts, when taken repeatedly, can increase the risk of inflammation, oxidative stress, and long-term toxicity. By contrast, pharmaceutical-grade methylene blue keeps contaminants at trace levels defined by USP safety standards, protecting both effectiveness and long-term health.
We work with pharmacy partners who confirm through allergen and raw material declarations that this formulation is non-GMO. Avoiding genetically modified inputs helps maintain product reliability and minimizes potential sensitivities for long-term use.
Hear from our patients
Remarkable Results in Just 3 Days
I just wanted to share how incredibly impressed I am with your methylene blue supplement. I’ve been taking a dose of approximately 16 mg, and within just three days, I’ve noticed a truly remarkable shift in my body.
Simon Levy
Amazing effect on my mental clarity
The methylene blue has had an amazing effect on my mental clarity and focus and the ability to recall and put my thoughts together and my energy level is greater now too! Literally I’ve had overall just a sense of better well being.
James J
Great products!
Very happy with my experience, the methylene blue especially helps a ton with my adhd and ability to focus, looking forward to more products coming out in the future.
Brent Lindstrom
Reviews
125 reviews
Frequently asked questions
Methylene blue is a prescription compound with antioxidant and mitochondrial-enhancing properties. It supports cellular energy by acting as an alternative electron carrier in the mitochondrial electron transport chain, especially under stress or dysfunction.
Yes, when clinically dosed. It has a long history of use and a well-documented safety profile. Our oral formulation is tested for heavy metals, potency, and purity.
No. Unlike liquid forms, our encapsulated methylene blue oral pills avoid staining and ensure optimal absorption.
Dosing is personalized, typically starting at 5 mg and gradually increasing to a maximum of 25 mg/day under clinical supervision. Low-dose regimens have shown strong cognitive benefits with minimal side effects
Early research supports its use for cognitive enhancement, mitochondrial support, fatigue, and inflammation. It may also benefit individuals with age-related mitochondrial dysfunction.
Consult your Healthspan clinician. It may interact with serotonergic medications (SSRIs/MAOIs) and should be avoided by individuals with G6PD deficiency.
Methylene blue is FDA-approved for specific uses such as methemoglobinemia. Its use for cognitive and mitochondrial support is off-label and guided by our medical team.
Yes. Many patients use methylene blue alongside Rapamycin, Metformin, or Oxytocin protocols for comprehensive healthspan support.
Some users may experience mild nausea, dizziness, or headache. Serious side effects are rare when used under supervision. Your care team will monitor and adjust dosing if needed.
While short-term use can yield noticeable results, longer-term use may support mitochondrial and cognitive aging. Your clinician can help determine the best timeline based on your goals.
Store in a cool, dry place away from direct light. No refrigeration required.
Methylene blue is not suitable for those with G6PD deficiency or those on contraindicated medications. Always consult your clinician before starting.
Methylene blue sold online is often industrial-grade or not intended for human use. These versions may contain contaminants, synthetic dyes, or inconsistent dosing, and they typically lack quality control or clinical oversight. In contrast, our formulation is pharmaceutical-grade, compounded in U.S.-certified pharmacies, and tested for purity, potency, and heavy metals. It is encapsulated to prevent staining and improve absorption, and prescribed with clinician supervision to ensure safe, personalized use
Methylene blue is a prescription compound with antioxidant and mitochondrial-enhancing properties. It supports cellular energy by acting as an alternative electron carrier in the mitochondrial electron transport chain, especially under stress or dysfunction.
Yes, when clinically dosed. It has a long history of use and a well-documented safety profile. Our oral formulation is tested for heavy metals, potency, and purity.
No. Unlike liquid forms, our encapsulated methylene blue oral pills avoid staining and ensure optimal absorption.
Dosing is personalized, typically starting at 5 mg and gradually increasing to a maximum of 25 mg/day under clinical supervision. Low-dose regimens have shown strong cognitive benefits with minimal side effects
Early research supports its use for cognitive enhancement, mitochondrial support, fatigue, and inflammation. It may also benefit individuals with age-related mitochondrial dysfunction.
Consult your Healthspan clinician. It may interact with serotonergic medications (SSRIs/MAOIs) and should be avoided by individuals with G6PD deficiency.
Methylene blue is FDA-approved for specific uses such as methemoglobinemia. Its use for cognitive and mitochondrial support is off-label and guided by our medical team.
Yes. Many patients use methylene blue alongside Rapamycin, Metformin, or Oxytocin protocols for comprehensive healthspan support.
Some users may experience mild nausea, dizziness, or headache. Serious side effects are rare when used under supervision. Your care team will monitor and adjust dosing if needed.
While short-term use can yield noticeable results, longer-term use may support mitochondrial and cognitive aging. Your clinician can help determine the best timeline based on your goals.
Store in a cool, dry place away from direct light. No refrigeration required.
Methylene blue is not suitable for those with G6PD deficiency or those on contraindicated medications. Always consult your clinician before starting.
Methylene blue sold online is often industrial-grade or not intended for human use. These versions may contain contaminants, synthetic dyes, or inconsistent dosing, and they typically lack quality control or clinical oversight. In contrast, our formulation is pharmaceutical-grade, compounded in U.S.-certified pharmacies, and tested for purity, potency, and heavy metals. It is encapsulated to prevent staining and improve absorption, and prescribed with clinician supervision to ensure safe, personalized use