Metabolic Optimization

Metabolic health is a key lever for health span optimization. Through metabolic health interventions we can help healthy cells be more efficient in utilizing energy, and cut off fuel sources for unhealthy dysfunctional cells.


Resveratrol is a naturally occurring molecule that its advocates believe activates Sirtuin genes. The expression of Sirtuin genes is believed to increase cellular autophagy, and also maintain the cells epigenome—ultimately resulting in healthier functional cells.

Strength of Research Rating
The strength of the research of resveratrol as a sirtuin activator is lacking.

Continuous Glucose Monitor

A Continuous Glucose Monitor gives you a direct view of how your food and lifestyle are affecting your blood sugar levels and your overall metabolic health. Based on the principles of bio-feedback, you can use these insights to make behavioral changes to optimize your metabolic health.

Strength of Research Rating
Everyone can benefit from a deeper understanding how what they eat impacts their metabolic health. This is in the no-brainer category.

Metformin + B12

Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy, and include optimizing metabolic pathways, and upregulating the molecules that maintain the epigenome.

Strength of Research Rating
Rating is based on extensive research into the safety and efficacy of Metformin and it's many modes of action to curtail age related disease.

Measure Your Body's Response to the Food Eat, Immediately

Getting real-time feedback on how the food you spikes your glucose levels is a powerful behavioral bio-feedback tool to change your eating habits, and optimize your metabolic health. By seeing how your body responds to the foods you eat, you can start to make changes to your diet and start optimizing your glucose levels to stay in a healthy range.

Fuel Healthy Cells, Starve the Dysfunctional Ones

Whether we are talking about senescent cells or injured cells that become cancerous, most dysfunctional cells have a common modus operandi: they are optimizing and constantly evolving to gain abundant access to fuel constant growth and proliferation.

Not all cancer cells are the same, and neither are senescent cells, but we know that many of these bad guys have a ravenous appetite for glucose. Glucose is not only the preferred fuel source, but oftentimes these dysfunctional cells have special ways of getting VIP access to glucose over healthy cells.

To make matters worse, when glucose rates are spiking, there are usually a bunch of nasty hormones flowing in your bloodstream exacerbating things. Insulin and its compadre Insulin Growth Factor-1, for example, provide these cells with signals to grow and replicate becoming fuel for the dysfunctional cell fire.

Metformin and the Metabolic Data

The reason Metformin is so widely studied as a healthspan promoting compound is the 60 years of obversational studies that linked its usage to low incidences of age-related chronic disease in diabetes patients. Remarkably patients diagnosed with diabetes—who theoretically would have more comorbidities—had less incidences of other diseases.

  • Cancer Mortality
  • Cancer Incidence
  • Cardiovascular Disease
  • Alzheimer
Health Span focuses on interventions that prevent healthy cells from becoming damaged cells, eradicating of existing damaged cells

The Pillars of Aging

What the Experts Are Saying (and doing)

Dr. David Sinclair

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.


How it works

  • 1
    Online visit

    Start your online visit by completing our new patient intake and providing information about your medical history and lifestyle. The online evaluation takes about 15-20 minutes to complete.

  • 2
    Doctor review

    A functional medicine physician will review the information you provide and determine the prescription that best suits your needs. Scripts are available for 1 month, 3 month, and 6 month supplies

  • 3
    Free shipping

    If prescribed, your treatment will be shipped directly to you, and arrive within 5-7 business days. All orders are tracked electronically, and you will have access to tracking for each shipment.

  • 4
    Ongoing Care

    Our messaging portal is available 24/7 to communicate with our functional medicine providers. For any questions you have about treatment, you are able to communicate directly with your physician.

Stand for Research

With every order Health Span will contribute $5 dollars to fund cancer research of the most promising metabolic oncology labs in the world.