Metabolic Optimization

Metabolic health is a key lever for health span optimization. Through metabolic health interventions, we can help healthy cells be more efficient in utilizing energy, and cut off fuel sources for unhealthy dysfunctional cells.


Acarbose is one of the most promising and clinically evaluated longevity molecules. Through its ability to block peak glucose levels, remodel gut microbiota, and increase GLP-1 levels, acarbose confers its powerful healthspan-promoting benefits.

Strength of Research Rating
The data that is available about acarbose is abundantly strong, and it has been used safely for many years.


Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome.

Strength of Research Rating
Rating is based on extensive research into the safety and efficacy of Metformin, and its many modes of action to curtail age related disease.

Measure Your Body's Response to the Food You Eat, Immediately

Getting real-time feedback on how the food you eat spikes your glucose levels is a powerful behavioral bio-feedback tool to change your eating habits, and optimize your metabolic health. By seeing how your body responds to the foods you eat, you can start to make changes to your diet and start optimizing your glucose levels to stay in a healthy range.

Fuel Healthy Cells, Starve the Dysfunctional Ones

Whether we are talking about senescent cells or injured cells that become cancerous, most dysfunctional cells have a common modus operandi: they are optimizing and constantly evolving to gain abundant access to fuel constant growth and proliferation.

Not all cancer cells are the same, and neither are senescent cells, but we know that many of these bad guys have a ravenous appetite for glucose. Glucose is not only the preferred fuel source, but oftentimes these dysfunctional cells have special ways of getting VIP access to glucose over healthy cells.

To make matters worse, when glucose rates are spiking, there are usually a bunch of nasty hormones flowing in your bloodstream, exacerbating things. Insulin and its compadre Insulin Growth Factor-1, for example, provide these cells with signals to grow and replicate, becoming fuel for the dysfunctional cell fire.

Metformin and the Metabolic Data

The reason Metformin is so widely studied as a healthspan-promoting compound is the 60 years of observational studies that linked its usage to low incidences of age-related chronic disease in diabetes patients. Remarkably patients diagnosed with diabetes—who theoretically would have more comorbidities—had fewer incidences of other diseases.

  • Cancer Mortality
  • Cancer Incidence
  • Cardiovascular Disease
  • Alzheimer
Health Span focuses on interventions that prevent healthy cells from becoming damaged cells, eradicating of existing damaged cells

The Pillars of Aging

What the Experts Are Saying (and doing)

Dr. David Sinclair

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.


How it works

  • 1
    Online visit

    Start your online visit by completing our new patient intake and providing information about your medical history and lifestyle. The online evaluation takes about 15-20 minutes to complete.

  • 2
    Doctor review

    A functional medicine physician will review the information you provide and determine the prescription that best suits your needs. Scripts are available for 1 month, 3 month, and 6 month supplies

  • 3
    Free shipping

    If prescribed, your treatment will be shipped directly to you, and arrive within 5-7 business days. All orders are tracked electronically, and you will have access to tracking for each shipment.

  • 4
    Ongoing Care

    Healthspan provides personalized strategies to optimize your health and longevity by monitoring key health indicators through regular check-ins and lab result reviews with your provider.

Stand for Research

With every order Health Span will contribute $5 dollars to fund cancer research of the most promising metabolic oncology labs in the world.