Senescence

Rapamycin
The most powerful tool to stop the acceleration of aging caused by mTOR dysfunction and cellular senescence.
Senescence
Senescence
The Cellular Renewal Stack offers a path to optimizing healthy aging by cycling two key blends: the Autophagy Blend and the AMPK Blend. This dual-phase approach aims to enhance cellular renewal, promote balanced metabolic regulation, and bolster overall vitality. By shifting between autophagy (deep cleanup) and AMPK activation (energy and metabolic optimization), the protocol keeps the body responsive, avoiding continuous stimulation of any single pathway. This cyclical strategy is an especially appealing option for those looking to expand beyond—or complement—their use of rapamycin, SGLT2 inhibitors, or other longevity therapies.
Starting at $105 /mo
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The Cellular Renewal Stack combines autophagy activation with AMPK support to clear cellular waste, balance growth signals, and build metabolic resilience. With targeted compounds like quercetin, spermidine, and dihydroberberine, it promotes steady energy, healthier aging, and long-term cellular vitality—designed to work seamlessly alongside other longevity therapies.
By incorporating both an autophagy-focused approach and an AMPK-supportive strategy, the Cellular Renewal Protocol helps remove dysfunctional proteins and organelles, potentially slowing age-related cellular decline.
The Protocol’s emphasis on metabolic optimization can improve glucose handling and fatty acid oxidation, contributing to steadier energy output and healthier blood sugar and lipid levels.
Rather than driving continuous anabolic activity, the Cellular Renewal Protocol supports intervals of necessary cellular repair. This balanced approach may mitigate the excessive mTOR stimulation often linked to accelerated aging.
Alternating between two distinct but complementary strategies helps prevent the body from adapting to a single signal, reducing plateau effects and maintaining long-term responsiveness.
Autophagy & Cellular Cleanup
AMPK Activation & Metabolic Efficiency
mTOR Pathway Regulation
NAD⁺ & Sirtuin Upregulation
Inflammation & Oxidative Stress Mitigation
Fasting-Mimetic Mechanisms
Mitochondrial Biogenesis & Renewal
Reduced Adaptation via Cycling
Autophagy is the cell’s built-in recycling system, essential for removing toxic aggregates and dysfunctional organelles. The Autophagy Blend contains quercetin phytosomes, spermidine, and L-ergothioneine—compounds investigated for upregulating autophagy-related genes (e.g., LC3) and pathways, fostering an environment of continual cellular renewal.
Cellular Renewal Stack
The Science
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Senescence
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The Cellular Renewal Stack is a cyclical regimen that involves two distinct blends: one designed to promote autophagy (cellular cleanup) and another formulated to activate AMPK (metabolic optimization). Upon starting, you receive both blends and select a cycle length—often a week or two—during which you devote the first portion of your chosen timeframe to the Autophagy Blend and the second portion to the AMPK Blend. Many people switch each week or follow another regular schedule that suits their lifestyle. This structure makes the protocol useful both as a standalone strategy and as a companion to medications like rapamycin or SGLT2 inhibitors.
The Cellular Renewal Stack is a cyclical regimen that involves two distinct blends: one designed to promote autophagy (cellular cleanup) and another formulated to activate AMPK (metabolic optimization). Upon starting, you receive both blends and select a cycle length—often a week or two—during which you devote the first portion of your chosen timeframe to the Autophagy Blend and the second portion to the AMPK Blend. Many people switch each week or follow another regular schedule that suits their lifestyle. This structure makes the protocol useful both as a standalone strategy and as a companion to medications like rapamycin or SGLT2 inhibitors.
Many individuals notice shifts in energy, workout recovery, or mental clarity within a few weeks, though deeper changes in metabolic markers—such as fasting glucose or lipid profiles—may take one to three months. Because the protocol is geared toward long-term cellular health, patience and consistency are essential.
Many individuals notice shifts in energy, workout recovery, or mental clarity within a few weeks, though deeper changes in metabolic markers—such as fasting glucose or lipid profiles—may take one to three months. Because the protocol is geared toward long-term cellular health, patience and consistency are essential.
All our supplements are made in a cGMP environment in a FDA registered facility.
All our supplements are made in a cGMP environment in a FDA registered facility.
We work with a cGMP certified and HACCP certified manufacturing plant. All testing for our products is done by a third party to ensure accuracy and integrity.
We work with a cGMP certified and HACCP certified manufacturing plant. All testing for our products is done by a third party to ensure accuracy and integrity.
There is no mandatory diet or workout program, but a minimally processed diet combined with moderate exercise typically enhances the benefits. Some participants add intermittent fasting or time-restricted eating to further support autophagy, though it’s not required to see results.
There is no mandatory diet or workout program, but a minimally processed diet combined with moderate exercise typically enhances the benefits. Some participants add intermittent fasting or time-restricted eating to further support autophagy, though it’s not required to see results.
If using Autophagy Blend alone, start with 1–2 capsules once or twice a day. Adjust based on how your body responds, and consider taking it with a light snack if you experience any digestive issues. If following the Cellular Renewal cycle, use the Autophagy Blend during the autophagy phase of your cycle, then switch to the AMPK Blend in the metabolic phase. For more details on this process, see the Cellular Renewal Stack.
If using Autophagy Blend alone, start with 1–2 capsules once or twice a day. Adjust based on how your body responds, and consider taking it with a light snack if you experience any digestive issues. If following the Cellular Renewal cycle, use the Autophagy Blend during the autophagy phase of your cycle, then switch to the AMPK Blend in the metabolic phase. For more details on this process, see the Cellular Renewal Stack.
If you miss a dose, simply continue where you left off as soon as you can. The protocol is designed to be flexible and forgiving, so small deviations won’t negate the long-term benefits. If you’re traveling, bring enough capsules to stick to your schedule as closely as possible, but don’t worry if occasional disruptions occur.
If you miss a dose, simply continue where you left off as soon as you can. The protocol is designed to be flexible and forgiving, so small deviations won’t negate the long-term benefits. If you’re traveling, bring enough capsules to stick to your schedule as closely as possible, but don’t worry if occasional disruptions occur.
Tracking markers such as fasting glucose, insulin, lipids, or inflammatory measures (like CRP) is not mandatory but can provide valuable insights into how well the protocol is working for you. Noticing stable or improving results over time usually indicates that the regimen is delivering its intended benefits.
Tracking markers such as fasting glucose, insulin, lipids, or inflammatory measures (like CRP) is not mandatory but can provide valuable insights into how well the protocol is working for you. Noticing stable or improving results over time usually indicates that the regimen is delivering its intended benefits.
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