Metabolic

Metformin

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Metabolic

Metformin

Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy and include optimizing metabolic pathways and upregulating the molecules that maintain the epigenome.

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    By testing for bioavailability, we're able to deliver medications that are more easily absorbed by your body, leading to improved outcomes and better overall health.

  • Prescribed In the US

    Our US-based clinicians are here to provide the guidance and support you need to achieve your health and longevity goals, and to address any concerns or questions you may have.

  • Dispensed by a LegitScript-certified Pharmacy

    All of our medications are pharmaceutical-grade and dispensed by a licensed pharmacist. We have extensively tested all of the formulations of our medications to offer our patients the highest biovailable medications.

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The Benefits of Metformin

A fasting mimetic that targets multiple longevity pathways, optimizes metabolic health, and increases autophagy.

Activates Multiple Longevity Pathways

Metformin effectively stimulates longevity pathways within the body, promoting overall well-being and potentially extending healthspan.

Reduces Insulin Resistance

Metformin has been shown to significantly decrease insulin resistance, helping to regulate blood sugar levels and potentially preventing the onset of type 2 diabetes.

Combats Inflammaging

By reducing chronic inflammation in the body, metformin can help counteract the effects of inflammaging, which is associated with various age-related diseases and conditions.

Boosts NAD+ Levels

Metformin has the potential to increase NAD+ levels, a coenzyme involved in energy metabolism and cellular repair processes, contributing to improved cellular health and function.

What aging pathways does metformin effect?

    What aging pathways does metformin effect?

  • Insulin/IGF-1 Signaling Pathway

  • AMP-activated Protein Kinase (AMPK) Activation

  • mTOR Pathway

  • Autophagy

  • Metabolic Regulation

  • Inflammation

  • Cellular Senescence

  • Oxidative Stress

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Insulin/IGF-1 Signaling Pathway image

Over time, our cells can become less responsive to insulin, a hormone crucial for regulating our blood sugar. It takes more and more insulin to transport glucose into a cell.

This increase in insulin corresponds with an increase in the hormone IGF-1, a growth hormone that stimulates cell growth.

As we age, the insulin/IGF-1 pathway may become overactive. The increased presence of IGF-1 can lead to abnormal cell growth and proliferation of both cancer cells and senescent cells.

Some scientific studies suggest that when IGF-1 activity is turned down a notch, it can lead to a longer, healthier life.

Metformin enhances our cells' response to insulin and turns down IGF-1 activity. This means a healthier metabolism and a reduced risk of conditions like type 2 diabetes. By fine-tuning cellular pathways linked to insulin and aging metformin improves healthspan.

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The Science of Metabolic Health

Metabolic health is a key lever for health span optimization. Through metabolic health interventions, we can help healthy cells be more efficient in utilizing energy, and cut off fuel sources for unhealthy dysfunctional cells.

Metformin and the Metabolic Data

    Metformin and the Metabolic Data

  • Cancer Mortality

  • Cancer Incidence

  • Cardiovascular Disease

  • Alzheimer

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Cancer Mortality image

Understanding

Metformin

The science

Metformin activates multiple longevity pathways, enhancing metabolic functions that regulate blood sugar levels and combat age-related cellular changes. This multifaceted approach not only aids in managing diabetes but also promotes a youthful physiological state, reducing signs of aging and bolstering overall health.

How Healthspan Works for You

We start with a personalized protocol designed to boost your performance and well-being, focusing on cellular senescence and metabolic optimization, with seamless online assessments, direct deliveries, and continuous optimization.

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Frequently asked questions about Metformin

How does metformin work in the body?

Metformin primarily works by reducing the amount of glucose produced by the liver and enhancing the sensitivity of muscle cells to insulin. This helps your body to better manage blood sugar levels, which in turn, can have long-term health benefits.

Metformin primarily works by reducing the amount of glucose produced by the liver and enhancing the sensitivity of muscle cells to insulin. This helps your body to better manage blood sugar levels, which in turn, can have long-term health benefits.

What is the typical dose of metformin for longevity purposes?

Your Healthspan assigned clinical team will review your medical history and biomarkers to make a recommendation for your metformin dosing protocol. The typical longevity dose can range from 500 to 1000 mg per day.

Your Healthspan assigned clinical team will review your medical history and biomarkers to make a recommendation for your metformin dosing protocol. The typical longevity dose can range from 500 to 1000 mg per day.

Is metformin safe for long-term use?

In general, metformin is considered safe for long-term use in managing diabetes. However, its long-term use for non-diabetic individuals for longevity purposes is still being researched. Regular check-ups are recommended to monitor for potential side effects.

In general, metformin is considered safe for long-term use in managing diabetes. However, its long-term use for non-diabetic individuals for longevity purposes is still being researched. Regular check-ups are recommended to monitor for potential side effects.

Do I need to worry about lactic acidosis while I am taking Metformin?

The risk of significant lactic acidosis associated with metformin is extremely rare when the medication is taken at appropriate doses and when the kidneys are functioning properly. However, as a precautionary measure, we recommend that patients discontinue metformin usage at least 3 days prior to undergoing any medical procedure or imaging that involves the use of contrast agents, such as a CT scan.

The risk of significant lactic acidosis associated with metformin is extremely rare when the medication is taken at appropriate doses and when the kidneys are functioning properly. However, as a precautionary measure, we recommend that patients discontinue metformin usage at least 3 days prior to undergoing any medical procedure or imaging that involves the use of contrast agents, such as a CT scan.

Can Metformin cause my blood sugar to drop too low?

Metformin is generally not known to cause dangerously low levels of blood sugar. However, it's important to note that individuals have varying tolerances for lower blood sugar levels. Therefore, some patients taking metformin may experience symptoms of low blood sugar, such as lightheadedness, nausea, or fatigue.

To minimize the risk of experiencing these symptoms, it is recommended to start metformin at a low dose and gradually increase it over time. This approach allows your body to adjust to the medication and helps mitigate the likelihood of blood sugar dropping too low.

Based on our experience, we have observed that most patients with a history of hypoglycemia can tolerate lower doses of metformin, typically starting at 500mg per day. However, it's essential to work closely with your healthcare provider to determine the most appropriate dosage for your specific needs.

By monitoring your blood sugar levels regularly and maintaining open communication with your healthcare team, you can ensure that metformin is effectively managing your blood sugar without causing it to drop to unsafe levels.

Metformin is generally not known to cause dangerously low levels of blood sugar. However, it's important to note that individuals have varying tolerances for lower blood sugar levels. Therefore, some patients taking metformin may experience symptoms of low blood sugar, such as lightheadedness, nausea, or fatigue.

To minimize the risk of experiencing these symptoms, it is recommended to start metformin at a low dose and gradually increase it over time. This approach allows your body to adjust to the medication and helps mitigate the likelihood of blood sugar dropping too low.

Based on our experience, we have observed that most patients with a history of hypoglycemia can tolerate lower doses of metformin, typically starting at 500mg per day. However, it's essential to work closely with your healthcare provider to determine the most appropriate dosage for your specific needs.

By monitoring your blood sugar levels regularly and maintaining open communication with your healthcare team, you can ensure that metformin is effectively managing your blood sugar without causing it to drop to unsafe levels.

How does Healthspan measure the effectiveness of the metformin protocol?

At Healthspan, we employ comprehensive methods to measure the effectiveness of our metformin protocol. We prioritize your well-being by conducting regular lab work that assesses your response to metformin. Our approach involves analyzing a range of biomarkers specifically associated with longevity, allowing us to gain valuable insights into the impact of metformin on your health.

One of the primary indicators we focus on is blood sugar levels. Patients taking metformin typically experience significant improvements in their ability to manage blood sugar, leading to better overall glycemic control. By tracking and monitoring these levels through lab testing, Healthspan can determine the effectiveness of metformin in this crucial aspect.

Moreover, we understand that evaluating your biological age is equally important. To provide a holistic assessment, we offer biological age testing, which allows you to compare your biological age with your chronological age. This unique feature enables you to gauge whether metformin is potentially slowing down your biological aging process in relation to your chronological aging.

Through our regular lab work and additional biological age testing, Healthspan ensures a thorough evaluation of the metformin protocol's impact on your health, allowing us to tailor our approach and support your well-being effectively.

At Healthspan, we employ comprehensive methods to measure the effectiveness of our metformin protocol. We prioritize your well-being by conducting regular lab work that assesses your response to metformin. Our approach involves analyzing a range of biomarkers specifically associated with longevity, allowing us to gain valuable insights into the impact of metformin on your health.

One of the primary indicators we focus on is blood sugar levels. Patients taking metformin typically experience significant improvements in their ability to manage blood sugar, leading to better overall glycemic control. By tracking and monitoring these levels through lab testing, Healthspan can determine the effectiveness of metformin in this crucial aspect.

Moreover, we understand that evaluating your biological age is equally important. To provide a holistic assessment, we offer biological age testing, which allows you to compare your biological age with your chronological age. This unique feature enables you to gauge whether metformin is potentially slowing down your biological aging process in relation to your chronological aging.

Through our regular lab work and additional biological age testing, Healthspan ensures a thorough evaluation of the metformin protocol's impact on your health, allowing us to tailor our approach and support your well-being effectively.

Where are my Metformin pills sourced from and what quality standards do they adhere to?

Our Metformin tablets meet stringent quality standards, similar to all pharmaceuticals sold within the United States, ensuring their safety and efficacy. While generic medications like Metformin might be sourced globally, it's important to note that regardless of their origin, all our medicines are dispensed and shipped from a U.S. based pharmacy that is registered and subject to routine inspections by the FDA. We prioritize your health and safety. As such, every medication you receive, including Metformin, has undergone rigorous manufacturing protocols and stringent approval processes. These standards align with those followed by national pharmacies, such as Walgreens and CVS, ensuring that the medications you receive from us are of the highest quality, regardless of their origin. We believe in transparency and are more than willing to provide further information about the manufacturing and dispensing processes of our products. Should you have any questions or need more information, our team is readily available to assist you.

Our Metformin tablets meet stringent quality standards, similar to all pharmaceuticals sold within the United States, ensuring their safety and efficacy. While generic medications like Metformin might be sourced globally, it's important to note that regardless of their origin, all our medicines are dispensed and shipped from a U.S. based pharmacy that is registered and subject to routine inspections by the FDA. We prioritize your health and safety. As such, every medication you receive, including Metformin, has undergone rigorous manufacturing protocols and stringent approval processes. These standards align with those followed by national pharmacies, such as Walgreens and CVS, ensuring that the medications you receive from us are of the highest quality, regardless of their origin. We believe in transparency and are more than willing to provide further information about the manufacturing and dispensing processes of our products. Should you have any questions or need more information, our team is readily available to assist you.

Does metformin influence weight loss or management?

A healthy lifestyle is recommended while taking metformin. This includes a balanced diet, regular exercise, adequate sleep, and reducing stress. These behaviors complement the potential longevity benefits of metformin.

A healthy lifestyle is recommended while taking metformin. This includes a balanced diet, regular exercise, adequate sleep, and reducing stress. These behaviors complement the potential longevity benefits of metformin.

Can metformin be taken in conjunction with other supplements or medications like rapamycin?

Metformin has a very high safety profile. There is over 60 years of data that demonstrates its high safety profile and therapeutic value. Your Healthspan physician will review your health history and current medications to see if metformin is appropriate for you.

Metformin has a very high safety profile. There is over 60 years of data that demonstrates its high safety profile and therapeutic value. Your Healthspan physician will review your health history and current medications to see if metformin is appropriate for you.

What are the side effects of metformin use?

Metformin can cause side effects, including digestive issues like nausea, vomiting, stomach upset, diarrhea, and a metallic taste in the mouth. Less common, but more serious side effects can include lactic acidosis, particularly in those with kidney issues.

Metformin can cause side effects, including digestive issues like nausea, vomiting, stomach upset, diarrhea, and a metallic taste in the mouth. Less common, but more serious side effects can include lactic acidosis, particularly in those with kidney issues.

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