The science of autophagy is the science of cellular rejuvination. Through the advent of autophagy enhancing therapies, we can trigger the cell's ability to recycle toxic misfolded proteins and debris to consume for energy, and revitalize a cell.
The Start of Cellular Dysfunction
One of the signature markers of an aged cell versus a young healthy cell is the presence of inflammation. If you were to examine a biopsy of an older person's cells, you would see visible signs of inflammation, whereas the younger person would be smoother and less inflamed. This is because as we get older, we have a higher proportion of inflammatory senescent cells.
The most obvious example of this phenomenon is in neurodegenerative diseases like Alzheimer's where dysfunctional cells accumulate an assortment of toxic Tau proteins that cause the cell to be attacked by our immune system.
Autophagy enhancers like Metformin, Rapamycin, and Intermittent Fasting turn on the cell's autophagy machinery to consume these toxic proteins to turn into cellular energy. This is the cells built in programming to preserve energy in states of nutrient deprivation, while simultaneoulsy creating a 'deep cleaning' phenomenon.
Inducing autophagy propels our cells into a healthier state and allows the tissues that they compose to carryout their original functions. Autophagy reduces the ratio of cellular senescent cells to healthy cells, removes toxic proteins from the cells that are attributed to nuerodegerative, cardiovascular, and cancer related disease.
Autophagy is a powerful evolutionary self-preservation mechanism through which the body can remove dysfunctional cells and toxic proteins responsible for many age related chronic diseases, and recycle parts of them toward cellular repair and cleaning.
Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy, and include optimizing metabolic pathways, and upregulating the molecules that maintain the epigenome.
Rapamycin is considered to be the most promising healthspan promoting interventions for its role in slowing down the formation of senescent cells through its inhibition of the mTOR complex 1 pathway.
We've put together a health kit that targets the three major longevity intervention pathways: senescence, autophagy, and metabolic health.
The Healthkit Includes
The Pillars of Aging
Dr. David Sinclair
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.
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