Rapamycin is considered to be the most promising health span promoting interventions for its role in slowing down the formation of senescent cells through its inhibition of the mTOR complex 1 pathway. By slowing down the formation of senescent cells and their harmful effects, Rapamycin usage effectively delays the onset of age related diseases.
The Pillars of Aging
Dr. David Sinclair
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.
Our Honest Assessment
Rapamycin shows the greatest potential as a medication that can slow down the formation of senescent cells and the corresponding age-related decline that comes with the higher ratio of dysfunctional senescent cells. Rapamycin binds directly to mTOR (complex 1) to induce cellular autophagy. By increasing autophagy through the inhibition mTOR, Rapamycin turns off the growth signals that drive senescent replication, reduces the inflammatory molecules (SASP) of senescent cells, and prevents healthy cells from becoming senescent cells.
More clinical trials need to be conducted to understand the proper dosing of Rapamycin for its off-lable use as an autophagy inducer. There is enough clinical data to understand the relative safety profile of Rapamycin when taken intermittently, however.
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