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Data-Driven Diets: How Dietary Fiber Influences Healthspan and Disease Resistance

This review article focuses on the critical role of dietary fiber in enhancing health outcomes and promoting longevity, underscoring its significance in disease prevention and lifespan extension. We synthesize existing research to explore the comprehensive effects of both soluble and insoluble dietary fibers on human health. Highlighting the importance of dietary fiber in improving digestive health, managing cholesterol levels, regulating diabetes, and maintaining overall gut health, this paper details how these indigestible carbohydrates positively influence metabolic processes, aid in weight management, and interact with the gut microbiota to generate beneficial short-chain fatty acids. Through a detailed case study on psyllium husk, we demonstrate the synergistic potential of dietary modifications alongside pharmacological approaches in the management of cholesterol, emphasizing the critical need to address the prevalent fiber deficiency in contemporary diets. Furthermore, we discuss the extensive public health implications of increasing fiber intake and outline the mechanisms by which dietary fiber can protect against various chronic diseases and enhance mortality rates. This article argues for a greater emphasis on fiber-rich foods within daily dietary practices, positioning dietary fiber as a powerful, yet underutilized, component in the pursuit of healthy aging.



19 mins

By: Agnieszka Balazy, MPharm, RPh


Dietary fiber, the indigestible part of plant foods, is renowned not only for its digestive benefits but also for its extensive role in enhancing overall health. It facilitates smooth bowel movements and fosters a healthy gut environment, which is foundational for effective digestion and nutrient absorption. Furthermore, fiber is instrumental in reducing cholesterol and blood sugar levels, offering a protective shield against conditions such as constipation, diverticulitis, and colon cancer. Its ability to induce feelings of fullness also makes it a valuable ally in weight management efforts.

Beyond these known benefits, recent studies have uncovered even more significant impacts. Studies suggest that a high-fiber diet can be a powerful weapon in preventing chronic age-related diseases like heart disease, diabetes, and even certain cancers. In this article, Agnieszka Balazy, MPharm, RPh delves into the latest research on how fiber can improve metabolic health and demonstrates how incorporating more fiber into your diet could substantially lower the risk of premature mortality.

Through a deeper exploration of fiber's diverse benefits, Balazy's analysis underscores the significance of fiber in a holistic health strategy, emphasizing its vital contribution to promoting overall healthspan. This comprehensive perspective encourages a more nuanced appreciation of fiber's impact on health and longevity.


When delving into the intricate relationship between nutrients and healthy aging, the role of dietary fiber often remains underappreciated. As a complex carbohydrate present in a variety of plant-based foods—such as fruits, vegetables, whole grains, legumes, and nuts—fiber offers a plethora of health advantages. These benefits range from enhancing digestive health and lowering cholesterol levels to mitigating the risk of various chronic diseases.

However, fiber is unique among nutrients, as it cannot be broken down or absorbed in the small intestine, unlike other carbohydrates that are typically converted into glucose. This resistance allows fiber to pass through the gastrointestinal tract relatively intact, where it plays a pivotal role in digestion and acts as a vital source of nourishment for the beneficial microbiota residing in the gut. The interaction between dietary fiber and gut bacteria is a key factor in maintaining gut health, which, in turn, has a significant impact on overall well-being and disease prevention. But what are the mechanisms behind this process?

There are two types of dietary fiber – soluble and insoluble - each one fulfilling a unique role.

  • Soluble fiber dissolves in water, forming a thick, gel-like paste in our digestive tract. Not only does it soften the stool mass, but it also facilitates regular bowel movements, preventing both diarrhea and constipation. Due to its consistency, it helps balance sugar levels and cholesterol. It makes you feel full for longer [1]. Some foods rich in soluble fiber are flax seeds, oats, beans, ripe bananas, apples, carrots, and tuber vegetables.

  • Insoluble fiber, in contrast, does not dissolve in water but adds bulk to the stool. Thanks to this form of fiber, you can avoid constipation and get rid of waste faster. You can get insoluble fiber from nuts, seeds, whole grains, and the skins of fruits and vegetables.

Most plant-based foods contain both types of fiber, but in different proportions, and the more processed the food, the more fiber is lost during its production.

Fiber and Digestion

A place where fiber plays the most prominent role is the digestive tract. Think of both fiber types as sponge and scrubber, working together to keep your gut and body healthy. Soluble fiber, much like a sponge, absorbs water and swells, playing a crucial part in regulating appetite and metabolism. This gel-forming fiber slows down the digestion process, thereby moderating glucose absorption and reducing fluctuations in blood sugar levels.

Insoluble fiber, conversely, acts as a scrubber for the gastrointestinal tract, enhancing the body's ability to process and eliminate waste. It achieves this by shortening the duration waste remains in the intestines, primarily through stimulating peristalsis—the rhythmic contractions of intestinal muscles.

The abrasive nature of insoluble fiber is instrumental in moving waste through the digestive tract. This movement is essential for the rapid passage of food residues, facilitating faster elimination of toxins and potentially harmful substances. By expediting the clearance of food and toxins, insoluble fiber plays a protective role against molecular damage from mutagens and carcinogens, which are substances capable of causing cancer [2].

Scientific research provides evidence for these mechanisms. A study published in the "World Journal of Gastroenterology" highlights how dietary fiber increases stool bulk and accelerates transit times through the colon, thus reducing the contact time between the intestinal mucosa and potential carcinogens [3]. Additionally, the role of dietary fiber in modulating the gut microbiota has been noted, with soluble fiber serving as a prebiotic that supports the growth of beneficial bacteria, further contributing to gut health and reducing the risk of inflammation and colorectal cancer [4].

Both types of fiber also help prevent constipation, hemorrhoids, and diverticulitis (common digestive disorders). [5]

Constipation, often perceived as a mere temporary discomfort, can have more serious implications than commonly thought. Chronic irregular bowel movements are linked to an increased risk of heart disease and colorectal cancer [6, 7, 8].

The link between constipation and colorectal cancer is thought to be related to the extended transit time of waste through the colon, which increases the intestinal lining's exposure to carcinogens in the stool. A meta-analysis in the "European Journal of Cancer" corroborates this by showing a significant association between constipation and an increased risk of colorectal cancer [9].

Prolonged constipation can also lead to hormonal imbalances. Hormones, the body's chemical messengers, need to be regularly expelled. When bowel movements are less frequent than three times a week, hormones linger in the gut for extended periods. This prolonged presence allows them to re-enter the bloodstream, potentially causing elevated levels, particularly of estrogen. Furthermore, certain gut bacteria produce an enzyme called beta-glucuronidase, which can reactivate hormones previously neutralized by the liver, exacerbating this imbalance [10, 11].

Fiber, Gut Health and Short-Chain Fatty Acids

The human digestive tract is more than a mere conduit for nutrients; it's a complex ecosystem, teeming with trillions of microorganisms, collectively termed the gut microbiome. These microbial inhabitants, predominantly located in the large intestine, are integral to physiological functions beyond digestion—they modulate immune responses, participate in metabolic processes, and can even influence psychological well-being.

The gut microbiota encompasses a wide array of microorganisms, including not only bacteria but also viruses, fungi, and protozoa. The composition and diversity of this microbiome are critical for maintaining health. Beneficial microbes, such as certain Bacteroidetes and Firmicutes, produce nutrients and metabolites that support gut integrity, prevent pathogen colonization, and modulate the immune system. Conversely, an overrepresentation of pathogenic microbes can disrupt this harmony, leading to dysbiosis—an imbalance linked to a host of disorders.

Recent advances in metagenomics and bioinformatics have illuminated the complexity of the gut microbiome and its contribution to health and disease. Research has demonstrated that a rich and diverse gut microbiome is associated with favorable health outcomes, while a depleted or imbalanced microbiome correlates with numerous diseases.

For example, an increase in certain species, such as those from the genus Faecalibacterium, which are known producers of butyrate—a short-chain fatty acid (SCFA) with anti-inflammatory properties—is associated with a healthy gut. In contrast, a rise in pro-inflammatory microbes, such as members of the Proteobacteria phylum, is often observed in conditions like obesity, type 2 diabetes, and IBD [12, 13].

Although our bodies lack the enzymes to digest dietary fiber, our gut microbes excel at this task. Soluble fiber, in particular, acts as a prebiotic, nourishing these beneficial microorganisms. They ferment soluble fiber into short-chain fatty acids (SCFAs), compounds that exert anti-inflammatory effects on the digestive system and contribute to maintaining gut health.

The presence of SCFAs has been associated with alleviating the symptoms of irritable bowel syndrome, decelerating the progression of inflammatory bowel disease, and inhibiting the growth of Clostridium difficile (C. diff), a dangerous infection that causes severe diarrhea [14, 15]. An extensive longitudinal study involving 170,000 participants over 26 years established a link between a high-fiber diet and a reduced risk of developing Crohn's disease, underscoring the protective role of dietary fiber against this chronic inflammatory condition [16].

But the benefits of SCFAs extend beyond the gut. These fatty acids play a crucial role in reducing inflammation, lowering the risk of colorectal cancer, enhancing immune function, regulating appetite, and even improving cognitive functions. This broad spectrum of benefits illustrates the integral role of dietary fiber and its fermentation products in health and disease prevention [17, 18, 19, 20].

By consuming more fiber, we can increase the number, variety, and activity of beneficial bacteria in our gut and simultaneously reduce the growth of harmful bacteria that cause inflammation and disease.

Remarkably, the positive shifts in the gut microbiome associated with increased fiber consumption can occur rapidly. Studies show that upping your fiber intake can induce positive changes in the gut microbiome in as short as two weeks [21]. This means that even a short-term dietary intervention can significantly impact our digestive health and overall well-being.

Fiber and Weight Loss

Dietary fiber, particularly the soluble type, plays a pivotal role in weight management strategies. Its ability to slow down food digestion contributes significantly to a prolonged sensation of satiety. This mechanism is essential for reducing overall appetite and, consequently, calorie consumption. Additionally, soluble fiber stimulates the release of cholecystokinin, a hormone that communicates with the brain to signal fullness, thereby helping to curb further food intake [22].

The impact of dietary fiber on weight loss and dietary adherence was exemplified in the POUNDS (Preventing Overweight Using Novel Dietary Strategies) clinical trial. Participants who increased their fiber intake reported enhanced feelings of fullness, which contributed to greater success in adhering to their weight loss plans. This outcome underlines the effectiveness of fiber as a tool in weight management and its potential to support long-term health goals [22].

Unlike some dietary components that can hinder the absorption of essential nutrients, fiber does not bind to vitamins and minerals, thereby preserving the nutritional integrity of the diet. This means that fiber can enhance our diet's nutritional quality without interfering with the availability of essential nutrients.

Fiber and Type 2 Diabetes

For those managing diabetes, the importance of both soluble and insoluble dietary fiber cannot be overstated. These two types of fiber complement each other in regulating blood sugar levels, an essential aspect of diabetes management. Soluble fiber, known for its gel-forming properties when mixed with water, plays a critical role in moderating the digestion and absorption of carbohydrates and fats—the main sources of glucose in the blood. By creating a viscous barrier in the digestive tract, soluble fiber ensures a slow, steady release of glucose into the bloodstream, mitigating the risk of the rapid spikes and dips in blood sugar levels that can be particularly detrimental to individuals with diabetes.

Insoluble fiber, although not directly involved in blood sugar management, contributes significantly by enhancing insulin sensitivity and lowering fasting blood glucose levels. This effect is particularly beneficial for individuals with diabetes who are overweight or obese. Improved insulin sensitivity means that the body's cells are better able to respond to insulin, facilitating the uptake of glucose from the bloodstream and thereby maintaining blood sugar levels within a healthy range.

The synergy between soluble and insoluble fiber in regulating blood sugar levels is supported by numerous studies. For instance, a meta-analysis published in "The Journal of the American Board of Family Medicine" found that increased dietary fiber intake, particularly soluble fiber, was associated with improved glycemic control in patients with type 2 diabetes [23]. Similarly, research in "Diabetes Care" has shown that diets high in insoluble fiber are associated with reductions in fasting blood glucose and improvements in insulin sensitivity [24].

These findings underscore the dual benefits of soluble and insoluble fiber for individuals with diabetes. By incorporating a variety of high-fiber foods into the diet, people with diabetes can achieve better blood sugar control, which is crucial for preventing the long-term complications associated with the condition. This holistic approach to dietary management, focusing on the quality and type of carbohydrates consumed, offers a practical and effective strategy for enhancing overall health and well-being in diabetes management [25, 26, 27, 28].

Fiber and Heart Health

The impact of dietary fiber on cardiovascular health is profound, especially when it comes to managing cholesterol levels, a key factor in heart disease prevention. Soluble fiber, in particular, plays a significant role in reducing levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol. This type of cholesterol is a primary contributor to plaque buildup in the arteries, which can lead to heart disease and stroke.

Soluble fiber's mechanism for lowering LDL cholesterol is twofold. Firstly, it acts like a sieve within the digestive system, capturing LDL cholesterol particles and facilitating their excretion from the body through the stool. Secondly, soluble fiber binds to bile acids in the gut. Bile acids are critical for the digestion and absorption of fats and are synthesized from cholesterol in the liver. By binding to these bile acids, soluble fiber prevents their reabsorption into the bloodstream, compelling the liver to utilize more cholesterol to produce additional bile acids. This process effectively lowers the overall cholesterol levels in the blood [29].

The significance of soluble fiber in cardiovascular health is supported by a wealth of scientific research. A meta-analysis published in the "American Journal of Clinical Nutrition" concluded that diets high in soluble fiber were associated with significant reductions in LDL cholesterol, without adversely affecting high-density lipoprotein (HDL) cholesterol, known as "good" cholesterol [30]. Additionally, a study in the "Journal of Nutrition" found that an increased intake of soluble fiber led to reductions in both total cholesterol and LDL cholesterol levels, further illustrating its protective role against cardiovascular disease [31].

By lowering cholesterol levels and preventing the reabsorption of bile acids, soluble fiber directly contributes to the prevention of plaque buildup in the arteries. This mechanism not only protects the heart and circulatory system from potential disease but also reduces the likelihood of heart attack and stroke. Given these benefits, incorporating soluble fiber-rich foods into the diet, such as oats, beans, lentils, and certain fruits, is a practical and effective strategy for enhancing cardiovascular health and mitigating the risk of cardiovascular diseases [32].

Case Study: Psyllium Husk and Cholesterol Reduction

A study from the Division of Cardiology Lipid Disorder Center, at the Robert Wood Johnson Medical School shines light on an unconventional but promising approach to reducing cholesterol: the addition of psyllium husk to standard cholesterol-lowering medication. This dietary supplement, derived from the seeds of the Plantago ovata plant, is known for its soluble fiber content and has been the subject of investigation in the context of hyperlipidemia management.

Background: The Fight Against High Cholesterol

High cholesterol, particularly elevated levels of low-density lipoprotein cholesterol (LDL-C), remains a significant risk factor for coronary heart disease (CHD). Statins, inhibitors of the HMG-CoA reductase enzyme, represent the cornerstone of treatment for individuals with high cholesterol, effectively reducing morbidity and mortality associated with coronary artery disease. However, the integration of dietary interventions alongside pharmacotherapy has been increasingly recognized for its potential to enhance therapeutic outcomes. Notably, the National Cholesterol Education Program's Adult Treatment Panel III guidelines have underscored the importance of incorporating viscous (soluble) fiber into the diet to aid in LDL-C reduction.

Study Overview: Psyllium Husk and Simvastatin

The 12-week, double-blind, placebo-controlled trial embarked on evaluating the LDL-C-lowering effect of psyllium husk when added to a regimen of low-dose simvastatin, a widely used statin.

Participants with hyperlipidemia were randomized into three groups, receiving either 20 mg of simvastatin plus a placebo, 10 mg of simvastatin plus a placebo, or 10 mg of simvastatin combined with 15 g of psyllium husk daily. The study assessed changes in total cholesterol, LDL-C, HDL-C (high-density lipoprotein cholesterol), triglycerides, and apolipoprotein B levels at the 4 and 8-week marks [33].

Findings: A Significant Impact on Cholesterol Levels

The results were compelling. Participants who supplemented their 10 mg simvastatin regimen with psyllium husk exhibited a significant reduction in LDL-C levels, specifically a reduction of 63 mg/dL, paralleling exactly the effects observed in those administered 20 mg of simvastatin alone.

The reduction in LDL-C levels—a primary target in the prevention of cardiovascular diseases—was noteworthy. LDL-C is commonly known as "bad" cholesterol because high levels can lead to a buildup of cholesterol in arteries and result in atherosclerosis, increasing the risk for heart attack and stroke. The study demonstrated that the addition of psyllium husk to a lower dose of simvastatin (10 mg) was as effective in reducing LDL-C levels as a higher dose of simvastatin (20 mg) alone. Apolipoprotein B (apoB) is another important measure in the assessment of cardiovascular risk. Each LDL particle contains one apoB molecule, so apoB levels can be a more precise measure of atherogenic particles than LDL-C levels alone. The parallel reduction observed for apoB and total cholesterol further solidifies the cardiovascular benefits of the combined treatment.

The fact that there were no significant changes in triglyceride or HDL-C levels is also meaningful. While triglycerides are another type of fat in the blood that can increase the risk of heart disease at high levels, HDL-C is considered "good" cholesterol because it helps remove other forms of cholesterol from the bloodstream. Maintaining these levels while reducing LDL-C and apoB suggests that the treatment specifically targets atherogenic cholesterol particles without negatively impacting other lipid fractions.

This indicates that psyllium husk supplementation could potentially halve the required dose of simvastatin for similar cholesterol-lowering effects, offering a valuable dietary adjunct to pharmacological treatment. The study further reported no significant adverse effects on triglyceride or HDL-C levels, reinforcing the safety and tolerability of psyllium husk.

By demonstrating that psyllium husk can enhance the efficacy of statin therapy, this study adds a valuable piece to the puzzle of comprehensive cardiovascular risk management. Moreover, it supports the notion that therapeutic lifestyle changes, particularly dietary modifications, play a crucial role in the management of high cholesterol.

Optimal Fiber Intake: Discrepancies and Implications for Mortality Reduction

Fiber has been long recognized for its digestive benefits and positive influence on metabolic health. Current dietary guidelines suggest consuming 25 to 30 grams of fiber daily [34]. This can be achieved by eating 1 cup of lentils, boiled broccoli, and raspberries each. Yet, the stark reality is that only 5% of Americans consume the daily recommended intake of fiber, despite its presence in readily available foods [35]. This lack of fiber consumption poses a significant health paradox in the United States, where such a potent dietary element is alarmingly absent from most dinner plates.

But why is fiber consumption so low? Some possible reasons include the availability and allure of processed foods, the lack of variety in plant foods, the popularity of elimination diets (such as Atkins, Whole30, ketogenic, and juice diets), and the misconception that fiber-rich foods are bland or expensive. But despite its indigestible nature, as recent research shows, fiber is indispensable for health and longevity.

A new study published in the Clinical Nutrition Journal reveals that higher consumption of dietary fiber significantly lowers the risk of death from any causes, as well as from primary chronic conditions like cardiovascular disease (CVD), cancer, and type 2 diabetes (T2D). These diseases are the leading causes of death, accounting for nearly 70% of mortality worldwide, so even a modest risk reduction could have a substantial impact on public health and individual life quality [25, 36]. This meta-analysis of 64 prospective studies is based on data from over 3 million patients, making it one of the largest and most comprehensive of its kind.

The study discovered that higher consumption of total dietary fiber lowered the risk of dying:

  • from any cause by 23%

  • from cardiovascular-related diseases, including stroke, by 26%

  • from cancer, especially colorectal cancer, by 22%

This is a powerful finding, suggesting that simply incorporating more fiber into your diet could increase your life expectancy and reduce your risk of developing chronic age-related diseases. It also indicates that this health benefit is relevant to everyone, not just limited to those with specific health concerns. The study also showed that different forms of fiber have various protective effects, with insoluble fiber being more effective in reducing the risk of total mortality and dying from cardiovascular diseases and cancer. Interestingly, the source of dietary fiber also matters, with fiber from whole grains, cereals, and vegetables showing a reduced risk of all-cause mortality. In contrast, dietary fiber from nuts and seeds is particularly effective in reducing the risk of heart and circulatory-related death by an impressive 43%.

Researchers found that even a tiny increase in fiber intake can make a difference; increasing the intake by just 10 grams per day - approximately one apple or a cup of cooked beans - was associated with a 15% drop in the risk of death from all causes and a 33% from colorectal cancer [25]. These findings offer valuable guidance for individuals aiming to make informed dietary choices that can contribute to a longer and healthier life, emphasizing the importance of including diverse sources of fiber in their daily nutrition.

Remember that fiber-rich foods also provide other beneficial compounds like phytochemicals, antioxidants, and vitamins, possibly contributing to their protective effects.

These outcomes are consistent with observations from previous studies investigating the link between fiber consumption and risk of death. The analysis of 17 studies on nearly one million patients published in the American Journal of Epidemiology showed that participants who consumed the highest amount of fiber in their diets were 16% less likely to die than participants with the lowest amounts of fiber. Additionally, it found that for every additional 10 grams of fiber a day, the risk of dying was down 10% [36].


We often overlook the power of seemingly simple choices. And while fiber is not the only solution, it remains a powerful one. A high-fiber diet can protect against chronic conditions like heart disease, stroke, diabetes, and certain cancers. By filling your plate with whole grains, fruits, vegetables, and legumes, you are not just nourishing your body - you nurture your gut microbiome, reduce inflammation, and regulate metabolism, potentially investing in a longer, healthier future. Research confirms the potential of fiber as a nutritional superhero. As our understanding of its mechanisms of action deepens, it becomes increasingly evident that incorporating enough dietary fiber into one's diet is an effective strategy for promoting overall well-being and staving off a spectrum of diseases. Embracing a fiber-abundant diet can help us rewrite the narrative of aging and set the stage for a healthier life.


  • Essential for Gut Health: Fiber is critical for maintaining gut health. It ensures regular bowel movements, prevents constipation, and feeds beneficial gut bacteria. This reduces inflammation and lowers the risk of developing issues like hemorrhoids, diverticulitis, and colorectal cancer.

  • Reduces Mortality Risk: A diet rich in fiber significantly lowers the risk of death from all causes, including major chronic diseases such as heart disease and cancer. The reduction in risk is nearly 25%, highlighting the importance of fiber in disease prevention.

  • Incremental Benefits: Small increases in fiber intake can have substantial health benefits. Adding just 10 grams of fiber per day (equivalent to an apple or a cup of cooked beans) can reduce the risk of death from various causes by 15%. This emphasizes the value of even minor dietary adjustments.

  • Aim for 25-30 grams Daily: To achieve these health benefits, aim to consume 25-30 grams of fiber each day. This can be done by including a variety of fruits, vegetables, legumes, and whole grains in your diet.

  • Additional Nutritional Advantages: Fiber-rich foods are also sources of vital phytochemicals, antioxidants, and vitamins. These compounds enhance the overall protective effects of a fiber-rich diet, contributing to better health and disease prevention.


  1. McRorie JW Jr, McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring Misconceptions about Insoluble and Soluble Fiber. J Acad Nutr Diet. 2017 Feb;117(2):251-264. doi: 10.1016/j.jand.2016.09.021. Epub 2016 Nov 15. PMID: 27863994.

  2. Song M, Wu K, Meyerhardt JA, Ogino S, Wang M, Fuchs CS, Giovannucci EL, Chan AT. Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018 Jan 1;4(1):71-79. doi: 10.1001/jamaoncol.2017.3684. Erratum in: JAMA Oncol. 2019 Apr 1;5(4):579. PMID: 29098294; PMCID: PMC5776713.

  3. Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: a series of systematic reviews and meta-analyses. The Lancet, 393(10170), 434-445.

  4. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr 22;5(4):1417-35. doi: 10.3390/nu5041417. PMID: 23609775; PMCID: PMC3705355.

  5. Crowe FL, Balkwill A, Cairns BJ, Appleby PN, Green J, Reeves GK, Key TJ, Beral V. Source of dietary fiber and diverticular disease incidence: a prospective study of UK women. Gut. 2014 Sep 1;63(9):1450-6.

  6. Sundbøll J, Thygesen SK, Veres K, Liao D, Zhao J, Gregersen H, Sørensen HT. Risk of cancer in patients with constipation. Clin Epidemiol. 2019 Apr 30;11:299-310. doi: 10.2147/CLEP.S205957. PMID: 31118818; PMCID: PMC6503315.

  7. Guérin A, Mody R, Fok B, Lasch KL, Zhou Z, Wu EQ, Zhou W, Talley NJ. Risk of developing colorectal cancer and benign colorectal neoplasm in patients with chronic constipation. Aliment Pharmacol Ther. 2014 Jul;40(1):83-92. doi: 10.1111/apt.12789. Epub 2014 May 15. PMID: 24832002.

  8. Ishiyama Y, Hoshide S, Mizuno H, Kario K. Constipation-induced pressor effects as triggers for cardiovascular events. J Clin Hypertens (Greenwich). 2019 Mar;21(3):421-425. doi: 10.1111/jch.13489. Epub 2019 Feb 13. PMID: 30761728; PMCID: PMC8030287.

  9. Power, A.M., Talley, N.J., & Ford, A.C. (2009). Association between constipation and colorectal cancer: Systematic review and meta-analysis of observational studies. European Journal of Cancer, 45(8), 1344-1353.

  10. Burr RL, Jarrett ME, Cain KC, Jun SE, Heitkemper MM. Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome. Neurogastroenterol Motil. 2009 Nov;21(11):1148-e97. doi: 10.1111/j.1365-2982.2009.01351.x. Epub 2009 Jul 1. PMID: 19573081; PMCID: PMC2820403.

  11. Pan R, Wang L, Xu X, Chen Y, Wang H, Wang G, Zhao J, Chen W. Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation. Nutrients. 2022 Sep 8;14(18):3704. doi: 10.3390/nu14183704. PMID: 36145079; PMCID: PMC9505360.

  12. Jin Y, Dong H, Xia L, Yang Y, Zhu Y, Shen Y, Zheng H, Yao C, Wang Y, Lu S. The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC. J Thorac Oncol. 2019 Aug;14(8):1378-1389. doi: 10.1016/j.jtho.2019.04.007. Epub 2019 Apr 23. PMID: 31026576.

  13. Zhou Z, Sun B, Yu D, Zhu C. Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus. Front Cell Infect Microbiol. 2022 Feb 15;12:834485. doi: 10.3389/fcimb.2022.834485. PMID: 35242721; PMCID: PMC8886906.

  14. Jiang W, Wu J, Zhu S, Xin L, Yu C, Shen Z. The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome. J Neurogastroenterol Motil. 2022 Oct 30;28(4):540-548. doi: 10.5056/jnm22093. PMID: 36250361; PMCID: PMC9577580.

  15. Ouyang ZR, Niu XR, Wang WG, Zhao JH. The role of short-chain fatty acids in Clostridioides difficile infection: A review. Anaerobe. 2022 Jun;75:102585. doi: 10.1016/j.anaerobe.2022.102585. Epub 2022 May 8. PMID: 35545183.

  16. Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, Fuchs CS, Willett WC, Richter JM, Chan AT. A prospective study of long-term intake of dietary fiber and risk of Crohn's disease and ulcerative colitis. Gastroenterology. 2013 Nov;145(5):970-7. doi: 10.1053/j.gastro.2013.07.050. Epub 2013 Aug 2. PMID: 23912083; PMCID: PMC3805714.

  17. Zhang F, Fan D, Huang J-l, Zuo T. The gut microbiome: linking dietary fiber to inflammatory diseases. Med Microecol. 2022;14:100070. doi:10.1016/j.medmic.2022.100070.

  18. Sivaprakasam S, Prasad PD, Singh N. Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis. Pharmacol Ther. 2016 Aug;164:144-51. doi: 10.1016/j.pharmthera.2016.04.007. Epub 2016 Apr 23. PMID: 27113407; PMCID: PMC4942363.

  19. Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. PMID: 32082260; PMCID: PMC7005631.

  20. Mirzaei R, Afaghi A, Babakhani S, Sohrabi MR, Hosseini-Fard SR, Babolhavaeji K, Khani Ali Akbari S, Yousefimashouf R, Karampoor S. Role of microbiota-derived short-chain fatty acids in cancer development and prevention. Biomed Pharmacother. 2021 Jul;139:111619. doi: 10.1016/j.biopha.2021.111619. Epub 2021 Apr 24. PMID: 33906079.

  21. Oliver A, Chase AB, Weihe C, Orchanian SB, Riedel SF, Hendrickson CL, Lay M, Sewall JM, Martiny JBH, Whiteson K. High-Fiber, Whole-Food Dietary Intervention Alters the Human Gut Microbiome but Not Fecal Short-Chain Fatty Acids. mSystems. 2021 Mar 16;6(2):e00115-21. doi: 10.1128/mSystems.00115-21. PMID: 33727392; PMCID: PMC8546969.

  22. Miketinas DC, Bray GA, Beyl RA, Ryan DH, Sacks FM, Champagne CM. Fiber Intake Predicts Weight Loss and Dietary Adherence in Adults Consuming Calorie-Restricted Diets: The POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study. J Nutr. 2019 Oct 1;149(10):1742-1748. doi: 10.1093/jn/nxz117. PMID: 31174214; PMCID: PMC6768815.

  23. Post, R.E., Mainous, A.G. III, King, D.E., & Simpson, K.N. (2012). Dietary fiber for the treatment of type 2 diabetes mellitus: A meta-analysis. The Journal of the American Board of Family Medicine, 25(1), 16-23.

  24. Weickert, M.O., & Pfeiffer, A.F.H. (2008). Metabolic effects of dietary fiber consumption and prevention of diabetes. Diabetes Care, 31(Supplement 1), S11-S12.

  25. Ramezani F, Pourghazi F, Eslami M, Gholami M, Mohammadian Khonsari N, Ejtahed HS, Larijani B, Qorbani M. Dietary fiber intake and all-cause and cause-specific mortality: An updated systematic review and meta-analysis of prospective cohort studies. Clin Nutr. 2024 Jan;43(1):65-83. doi: 10.1016/j.clnu.2023.11.005. Epub 2023 Nov 14. PMID: 38011755.

  26. Role of Fiber in Preventing and Treating Diabetes. Centers for Disease Control and Prevention. Retrieved: January 26, 2024  from

  27. Kabisch S, Honsek C, Kemper M, Gerbracht C, Arafat AM, Birkenfeld AL, Dambeck U, Osterhoff MA, Weickert MO, Pfeiffer AFH. Dose-dependent effects of insoluble fibre on glucose metabolism: a stratified post hoc analysis of the Optimal Fibre Trial (OptiFiT). Acta Diabetol. 2021 Dec;58(12):1649-1658. doi: 10.1007/s00592-021-01772-0. Epub 2021 Jul 12. PMID: 34254189; PMCID: PMC8542533.

  28. Weickert MO, Möhlig M, Schöfl C, Arafat AM, Otto B, Viehoff H, Koebnick C, Kohl A, Spranger J, Pfeiffer AF. Cereal fiber improves whole-body insulin sensitivity in overweight and obese women. Diabetes Care. 2006 Apr;29(4):775-80. doi: 10.2337/diacare.29.04.06.dc05-2374. PMID: 16567814.

  29. Gunness P, Gidley MJ. Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides. Food Funct. 2010 Nov;1(2):149-55. doi: 10.1039/c0fo00080a. Epub 2010 Sep 30. PMID: 21776465.

  30. Brown, L., Rosner, B., Willett, W.W., & Sacks, F.M. (1999). Cholesterol-lowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition, 69(1), 30-42.

  31. Fernandez, M.L., & Webb, D. (2008). The LDL to HDL cholesterol ratio as a valuable tool to evaluate coronary heart disease risk. Journal of the American College of Nutrition, 27(1), 1-5.

  32. McRae MP. Dietary Fiber Is Beneficial for the Prevention of Cardiovascular Disease: An Umbrella Review of Meta-analyses. J Chiropr Med. 2017 Dec;16(4):289-299. doi: 10.1016/j.jcm.2017.05.005. Epub 2017 Oct 25. PMID: 29276461; PMCID: PMC5731843.

  33. Moreyra AE, Wilson AC, Koraym A. Effect of Combining Psyllium Fiber With Simvastatin in Lowering Cholesterol. Arch Intern Med. 2005;165(10):1161–1166. doi:10.1001/archinte.165.10.1161

  34. Mayo Clinic Staff. High-fiber foods. Mayo Clinic.. Published: November 23, 2023. Retrieved: January 25, 2024 from

  35. Ioniță-Mîndrican CB, Ziani K, Mititelu M, Oprea E, Neacșu SM, Moroșan E, Dumitrescu DE, Roșca AC, Drăgănescu D, Negrei C. Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review. Nutrients. 2022 Jun 26;14(13):2641. doi: 10.3390/nu14132641. PMID: 35807822; PMCID: PMC9268622.

  36. Yang Y, Zhao LG, Wu QJ, Ma X, Xiang YB. Association between dietary fiber and lower risk of all-cause mortality: a meta-analysis of cohort studies. Am J Epidemiol. 2015 Jan 15;181(2):83-91. doi: 10.1093/aje/kwu257. Epub 2014 Dec 31. PMID: 25552267


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