Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy, and include optimizing metabolic pathways, and upregulating the molecules that maintain the epigenome.
The Pillars of Aging
Dr. David Sinclair
David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.
* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.
Our Honest Assessment
There is over 60 years of data demonstrating the efficacy and safety of Metformin, both as metabolic-optimizer, but also as a prophylactic against many age-related diseases. Because of its safety profile, and the many observational studies that show lower mortality rates, and occurence of cardiovascular, neurodegenerative disease, and cancer, researchers have now focused on the mechanistic actions of Metformin as an autophagy inducer, as well as its upregulation of other longevity pathways.
The reason Metformin is so widely studied as a healthspan promoting compound is the 60 years of obversational studies that linked its usage to low incidences of age-related chronic disease in diabetes patients. Remarkably patients diagnosed with diabetes—who theoretically would have more comorbidities—had less incidences of other diseases.
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