Metformin + B12

Metformin is one of the most promising and well-researched interventions to slow down the accumulation of senescent cells by inducing autophagy. Metformin's benefits extend beyond the induction of autophagy, and include optimizing metabolic pathways, and upregulating the molecules that maintain the epigenome.

FDA-approved medication
Prescribed by functional medical physicians
Online Intake and ongoing check-ins

The Pillars of Aging

What the Experts Are Saying (and doing)

Dr. David Sinclair

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

* Dr. David Sinclair is not involved with Healthspan and does not sell Metformin.

The Benefits of Metformin

Our Honest Assessment

There is over 60 years of data demonstrating the efficacy and safety of Metformin, both as metabolic-optimizer, but also as a prophylactic against many age-related diseases. Because of its safety profile, and the many observational studies that show lower mortality rates, and occurence of cardiovascular, neurodegenerative disease, and cancer, researchers have now focused on the mechanistic actions of Metformin as an autophagy inducer, as well as its upregulation of other longevity pathways.

Robust Research

Metformin and the Metabolic Data

The reason Metformin is so widely studied as a healthspan promoting compound is the 60 years of obversational studies that linked its usage to low incidences of age-related chronic disease in diabetes patients. Remarkably patients diagnosed with diabetes—who theoretically would have more comorbidities—had less incidences of other diseases.

  • Cancer Mortality
  • Cancer Incidence
  • Cardiovascular Disease
  • Alzheimer
Health Span focuses on interventions that prevent healthy cells from becoming damaged cells, eradicating of existing damaged cells

How it works

  • 1
    Online visit

    Start your online visit by completing our new patient intake and providing information about your medical history and lifestyle. The online evaluation takes about 15-20 minutes to complete.

  • 2
    Doctor review

    A functional medicine physician will review the information you provide and determine the prescription that best suits your needs. Scripts are available for 1 month, 3 month, and 6 month supplies

  • 3
    Free shipping

    If prescribed, your treatment will be shipped directly to you, and arrive within 5-7 business days. All orders are tracked electronically, and you will have access to tracking for each shipment.

  • 4
    Ongoing Care

    Our messaging portal is available 24/7 to communicate with our functional medicine providers. For any questions you have about treatment, you are able to communicate directly with your physician.